What You Need to Know About Supplement Interactions

Did you know that some of the most common medications—both over-the-counter and prescription—can quietly deplete your body of essential nutrients? Or that certain supplements might interfere with how well those medications work—or even amplify their effects?

In my recent segment on Breakfast Television, we tackled the often-overlooked world of drug-nutrient interactions. Below is a summary of the six most common medication types and how supplements can either hinder or support your health while you’re on them.

Over-the-Counter Medications

1. Pain Relievers (NSAIDs – aspirin, ibuprofen, acetaminophen)
   Garlic and Ginkgo biloba may increase the risk of bleeding when taken with NSAIDs.
   NAC (N-acetylcysteine) and Glutathione help protect the liver from acetaminophen damage and reduce oxidative stress.
   Omega-3 fatty acids may complement NSAIDs by further reducing inflammation.
2. Antacids (e.g., calcium carbonate, magnesium hydroxide, aluminum hydroxide)
   Combining calcium supplements with antacids can lead to hypercalcemia, which may result in kidney stones, heart issues, or impaired bone health. These should be taken at least three hours apart.
   Magnesium citrate helps restore magnesium levels that long-term antacid use can deplete.
   Probiotics can help maintain gut microbiome health, which is often disrupted by changes in stomach acid.
3. Antihistamines (e.g., diphenhydramine, loratadine, cetirizine)
   Kava, valerian root, and melatonin may intensify sedation when taken with first-generation antihistamines.
   St. John’s Wort may reduce the effectiveness of second-generation antihistamines by altering their metabolism.
   Vitamin C helps support immune function and may reduce the need for ongoing antihistamine use.
   Quercetin, a natural bioflavonoid, works similarly to an antihistamine to reduce allergic symptoms.

Prescription Medications

4. Statins (for high cholesterol)
   Red yeast rice contains natural statins and can intensify side effects when taken alongside prescription statins.
   Coenzyme Q10 (CoQ10) levels are depleted by statins; supplementing can help reduce muscle pain and fatigue.
   Vitamin D may improve statin tolerance and support cardiovascular health.
5. Antidepressants (SSRIs – sertraline, fluoxetine, escitalopram)
   5-HTP (5-Hydroxytryptophan) should not be taken with SSRIs, as it can dangerously raise serotonin levels and potentially cause serotonin syndrome.
   B-Complex vitamins, especially B6, B12, and folate, are important for mood regulation and can help reduce SSRI-related fatigue.
   L-theanine promotes relaxation and helps reduce anxiety without interfering with serotonin.
6. Metformin (for diabetes)
   Berberine and metformin lower blood sugar through similar mechanisms. Taken together, they may cause dangerously low blood sugar.
   Magnesium helps replenish levels that may be depleted by metformin and supports metabolic health and muscle function.
   Alpha-lipoic acid (ALA) supports insulin sensitivity and helps reduce oxidative stress in individuals with diabetes.

Final Thoughts

Supplements can be powerful allies in health optimization, but they must be used wisely, especially when combined with medication. Some may enhance drug effects, others may cancel them out, and some combinations can lead to serious health concerns.

Before adding new supplements, especially if you’re currently on prescription or OTC medications, consult a qualified healthcare provider. I’m here to help guide you through personalized options.