Nutritional Supplement

Yohimbe for Sports & Fitness

Yohimbe
  • Men's Health

    Erectile Dysfunction

    Yohimbe appears to increase blood flow and dilate blood vessels.
    Erectile Dysfunction
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    Yohimbine (the primary active constituent in yohimbe) has been shown in several double-blind trials to help treat men with ED;13,14 negative results have also been reported, however.15,16 Yohimbe dilates blood vessels and may help, regardless of the cause of ED. A tincture of yohimbe bark is often used in the amount of 5 to 10 drops three times per day. Standardized yohimbe extracts are also available. A typical daily amount of yohimbine is 15 to 30 mg. It is best to use yohimbe and yohimbine under the supervision of a physician.

  • Sexual Health

    Erectile Dysfunction

    Yohimbe appears to increase blood flow and dilate blood vessels.
    Erectile Dysfunction
    ×
     

    Yohimbine (the primary active constituent in yohimbe) has been shown in several double-blind trials to help treat men with ED;17,18 negative results have also been reported, however.19,20 Yohimbe dilates blood vessels and may help, regardless of the cause of ED. A tincture of yohimbe bark is often used in the amount of 5 to 10 drops three times per day. Standardized yohimbe extracts are also available. A typical daily amount of yohimbine is 15 to 30 mg. It is best to use yohimbe and yohimbine under the supervision of a physician.

  • Weight Management

    Obesity

    Yohimbine, a nervous system stimulant found in yohimbe bark, may help weight loss by raising metabolic rate, reducing appetite, and increasing fat burning.
    Obesity
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    The ability of yohimbine, a chemical found in yohimbe bark, to stimulate the nervous system and promote the breakdown of fat tissue has led to claims that it might help weight loss by raising metabolic rate, reducing appetite, and increasing fat burning. A placebo-controlled trial that included 20 women on a low-calorie weight-loss diet found those taking 5 mg of yohimbine four times per day had increased energy expenditure and greater weight loss after three weeks.21 However, a similar trial that included 47 men, taking 43 mg per day of yohimbine for six months resulted in no effect on weight loss.22 Because of its effects on the nervous system, yohimbine increases heart rate, blood pressure, and impulsivity23; therefore, it is recommended those wishing to use yohimbine for weight loss first consult their health care practitioner.
  • Fitness

    Athletic Performance

    Yohimbine has shown an ability to stimulate the nervous system, promote the release of fat from fat cells, and affect the cardiovascular system.
    Athletic Performance
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    The ability of yohimbine, a chemical found in yohimbe bark, to stimulate the nervous system,24,25 promote the release of fat from fat cells,26,27 and affect the cardiovascular system 28 has led to claims that yohimbe might help athletic performance or improve body composition. However, a double-blind study of men who were not dieting reported no effect of up to 43 mg per day of yohimbine on weight or body composition after six months.29 No research has tested yohimbe herb for effects on body composition, and no human research has investigated the ability of yohimbine or yohimbe to affect athletic performance. Other studies have determined that a safe daily amount of yohimbine is 15 to 30 mg.30 However, people with kidney disorders should not take yohimbe, and side effects of nausea, dizziness, or nervousness may occur that necessitate reducing or stopping yohimbe supplementation.

  • Stress and Mood Management

    Depression

    Yohimbine (the active component of yohimbe) inhibits monoamine oxidase and therefore may be beneficial in treating depression.
    Depression
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    Damiana has traditionally been used to treat people with depression. Yohimbine (the active component of the herb yohimbe) inhibits monoamine oxidase (MAO) and therefore may be beneficial in depressive disorders. However, clinical research has not been conducted for its use in treating depression.

What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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Traditional Use (May Not Be Supported by Scientific Studies)

Historically, yohimbe bark was used in western Africa for fevers, leprosy, and coughs.31 It has also been used to dilate pupils, for heart disease, and as a local anesthetic. It has a more recent history of use as an aphrodisiac and a hallucinogen.

References

1. Riley AJ. Yohimbine in the treatment of erectile disorder. Br J Clin Pract 1994;48:133-6.

2. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

3. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

4. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

5. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

6. Mosqueda-Garcia R, Fernandez-Violante R, Tank J, et al. Yohimbine in neurally mediated syncope. Pathophysiological implications. J Clin Invest 1998;102:1824-30.

7. Goldberg MR, Robertson D. Yohimbine: a pharmacological probe for the study of the alpha 2-adrenoceptor. Pharmacol Rev 1983;35:143-180

8. Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988;18:587-94.

9. Zahorska-Markiewicz B, Kucio C, Piskorska D. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res 1986;18:693-7.

10. Waluga M, Janusz M, Karpel E, et al. Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women. Clin Physiol 1998;18:69-76.

11. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

12. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

13. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

14. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

15. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

16. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

17. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

18. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

19. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

20. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

21. Kucio C, Jonderko K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci 1991;27:550–6.

22. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

23. Swann AC, Lijffijt M, Lane SD, et al. Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology (Berl) 2013 Sep;229(1):83–94.

24. Mosqueda-Garcia R, Fernandez-Violante R, Tank J, et al. Yohimbine in neurally mediated syncope. Pathophysiological implications. J Clin Invest 1998;102:1824-30.

25. Goldberg MR, Robertson D. Yohimbine: a pharmacological probe for the study of the alpha 2-adrenoceptor. Pharmacol Rev 1983;35:143-180

26. Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988;18:587-94.

27. Zahorska-Markiewicz B, Kucio C, Piskorska D. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res 1986;18:693-7.

28. Waluga M, Janusz M, Karpel E, et al. Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women. Clin Physiol 1998;18:69-76.

29. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

30. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

31. Duke J. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 351.

32. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

33. Drug Facts and Comparisons. St. Louis: Facts and Comparisons, 1998, 3659.

34. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 382-3.

35. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

36. Friesen K, Palatnick W, Tenenbein M. Benign course after massive ingestion of yohimbine. J Emerg Med 1993;11:287-8.

37. Bremner JD, Innis RB, Ng CK, et al. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1997;54:246-54.

38. Charney DS, Woods SW, Goodman WK, Heninger GR. Neurobiological mechanisms of panic anxiety: Biochemical and behavioral correlates of yohimbine-induced panic attacks. Am J Psychiatry 1987;144:1030-6.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.