Nutritional Supplement

Olive Leaf

Side Effects

The safety of olive leaf has not been established in pregnancy. Olive leaf can be irritating to the stomach lining and should be taken with meals.24

References

1. Wren RC. Potter's New Cyclopedia of Botanical Drugs and Preparations. Essex, England: CW Daniel Co., 1985, 204.

2. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Technique & Documentation-Lavoisier, 1995, 487-9.

3. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Technique & Documentation-Lavoisier, 1995, 487-9.

4. Petkov V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 1972;22:1476-86.

5. Weiss RF. Herbal Medicine. Gothenburg, Sweden: AB Arcancum, 1988, 160-1.

6. Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sciences 1994;55:1965-71.

7. Fleming HP, Walter WM, Etchells JL. Antimicrobial properties of oleuropein and products of its hydrolysis from green olives. Applied Microbiol 1973;26:777-82.

8. Peirce A. Practical Guide to Natural Medicines. New York: William Morrow and Co., 1999, 469-71.

9. Romani A, Ieri F, Urciuoli S, et al. Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L. Nutrients 2019;11:1776.

10. Hermans MP, Lempereur P, Salembier JP, et al. Supplementation Effect of a Combination of Olive (Olea europea L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome. Antioxidants (Basel) 2020;9:872.

11. Lockyer S, Rowland I, Spencer JPE, et al. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr 2017;56:1421–32.

12. Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011;18:251–8.

13. Takeda R, Koike T, Taniguchi I, Tanaka K. Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis. Phytomedicine 2013;20:861–64.

14. Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012;15:605–10.

15. Florentin M, Liberopoulos E, Elisaf M, Tsimihodimos V. No effect of fenugreek, bergamot and olive leaf extract on glucose homeostasis in patients with prediabetes: a randomized double-blind placebo-controlled study. Arch Med Sci Atheroscler Dis 2019;4:e162-e166.

16. Araki R, Fujie K, Yuine N, et al. Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial. Nutr Res 2019;67:60–6.

17. de Bock M, Derraik J, Brennan C, et al. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS One 2013;8:e57622.

18. Almalki D, Alghamdi S, Al-Attar A. Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats. Biomed Res Int 2019;2019:3596287.

19. Park J, Jung J, Yang J, Kim H. Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice. Nutr Res 2013;33:942–51.

20. Cvjeticanin T, Miljkovic D, Stojanovic I, et al. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br J Nutr 2010;103:1413–24.

21. Grieve M. A Modern Herbal, vol II. New York: Dover Publications, 1982, 598.

22. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 148-9.

23. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 148-9.

24. Petkov V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 1972;22:1476-86.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.