Nutritional Supplement

Olive Leaf

Parts Used & Where Grown

Olive is a small evergreen tree native to Mediterranean regions. The characteristic green to blue-black fruit of this tree yields a useful, edible oil. Both the oil and the dried green-grayish colored leaves are used medicinally.1,2

How It Works

Olive leaf has a wide number of constituents, including oleuropein and several types of flavonoids (e.g., rutin, apigenin, luteolin).3 While olive leaf is traditionally associated with a wide number of medicinal claims, few of these have been verified by experimental study. In an animal study oleuropein (when given by injection or in intravenous form) was found to decrease blood pressure (e.g., systolic and diastolic) and dilate the coronary arteries surrounding the heart.4 This ability to lower blood pressure may justify the traditional use of olive leaf in the treatment of mild to moderate hypertension.5 However, human studies are needed to clearly establish olive leaf as a potential treatment for high blood pressure.

In addition, a test tube study has revealed that oleuropein inhibits the oxidation of LDL (“bad”) cholesterol. LDL oxidation is one part in a series of damaging events that, if left unchecked, can lead to the development of atherosclerosis.6 This action may provide one clue as to why those consuming a Mediterranean-based diet may lower their risk of developing atherosclerosis.

Oleuropein from olives may also have antibacterial properties. When unheated olives are brined to preserve them, oleuropein is converted into another chemical called elenolic acid. Elenolic acid has shown antibacterial actions against several species of Lactobacilli and Staphylococcus aureus and Bacillus subtilus in a test tube study.7 Whether or not the oleuropein in the leaf undergoes such a transformation is open to question at this point, raising some question as to its antibacterial effects and potential use for this purpose in humans.

Olive leaf extracts have been employed experimentally to lower elevated blood-sugar levels in animals with diabetes.8 These results have not been reproduced in human clinical trials and as such, no clear conclusions can be made from this animal study in the treatment of diabetes.

References

1. Wren RC. Potter's New Cyclopedia of Botanical Drugs and Preparations. Essex, England: CW Daniel Co., 1985, 204.

2. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Technique & Documentation-Lavoisier, 1995, 487-9.

3. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Technique & Documentation-Lavoisier, 1995, 487-9.

4. Petkov V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 1972;22:1476-86.

5. Weiss RF. Herbal Medicine. Gothenburg, Sweden: AB Arcancum, 1988, 160-1.

6. Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sciences 1994;55:1965-71.

7. Fleming HP, Walter WM, Etchells JL. Antimicrobial properties of oleuropein and products of its hydrolysis from green olives. Applied Microbiol 1973;26:777-82.

8. Peirce A. Practical Guide to Natural Medicines. New York: William Morrow and Co., 1999, 469-71.

9. Romani A, Ieri F, Urciuoli S, et al. Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L. Nutrients 2019;11:1776.

10. Hermans MP, Lempereur P, Salembier JP, et al. Supplementation Effect of a Combination of Olive (Olea europea L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome. Antioxidants (Basel) 2020;9:872.

11. Lockyer S, Rowland I, Spencer JPE, et al. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr 2017;56:1421–32.

12. Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011;18:251–8.

13. Takeda R, Koike T, Taniguchi I, Tanaka K. Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis. Phytomedicine 2013;20:861–64.

14. Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012;15:605–10.

15. Florentin M, Liberopoulos E, Elisaf M, Tsimihodimos V. No effect of fenugreek, bergamot and olive leaf extract on glucose homeostasis in patients with prediabetes: a randomized double-blind placebo-controlled study. Arch Med Sci Atheroscler Dis 2019;4:e162-e166.

16. Araki R, Fujie K, Yuine N, et al. Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial. Nutr Res 2019;67:60–6.

17. de Bock M, Derraik J, Brennan C, et al. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS One 2013;8:e57622.

18. Almalki D, Alghamdi S, Al-Attar A. Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats. Biomed Res Int 2019;2019:3596287.

19. Park J, Jung J, Yang J, Kim H. Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice. Nutr Res 2013;33:942–51.

20. Cvjeticanin T, Miljkovic D, Stojanovic I, et al. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br J Nutr 2010;103:1413–24.

21. Grieve M. A Modern Herbal, vol II. New York: Dover Publications, 1982, 598.

22. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 148-9.

23. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 148-9.

24. Petkov V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneimittelforschung 1972;22:1476-86.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.