Nutritional Supplement

Garcinia cambogia

Where to Find It

HCA is found in only a few plants, with one rich source being the rind of a little pumpkin-shaped fruit called Garcinia cambogia, which is native to Southeast Asia. This fruit (also called Malabar tamarind) is used as a condiment in dishes such as curry.

How to Use It

Optimal amounts of HCA remain unknown. Although dieters sometimes take 500 mg of HCA three times per day (before each meal), this amount is far below the levels used in animal research (figured on a per-pound body weight basis). The effect of HCA is enhanced when used in conjunction with a low-fat diet, because HCA does nothing to reduce the caloric effects of dietary fat. Since HCA’s mechanism of action seems to be at least partially a blockade of conversion of simple sugars into fats,12 it is likely to work best in conjunction with a high simple sugar diet. HCA may therefore be less useful if it only offsets the negative effects of an otherwise unhealthy diet. High-fiber diets may impair absorption of HCA as noted above. HCA supplements are available in many forms, including tablets, capsules, powders, snack bars, and chewing gum.

References

1. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971;246:629-32.

2. Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357-63.

3. Cheema-Dhadli S, Harlperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem 1973;38:98-102.

4. Sullivan AC, Hamilton JG, Miller ON, et al. Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch Biochem Biophys 1972;150:183-90.

5. Greenwood MRC, Cleary MP, Gruen R, et al. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am J Physiol 1981;240:E72-8.

6. Sullivan AC, Triscari J. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr 1977;30:767-76.

7. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis. Lipids 1974;9:121-8.

8. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of(-)-hydroxycitrate upon the accumulation of lipid in the rat: II. Appetite. Lipids1974;9:129-34.

9. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitricacid) as a potential antiobesity agent: a randomized controlled trial. JAMA1998;280:1596-600.

10. Martinet A, Hostettmann K, Schultz Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine 1999;6:231-8.

11. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 2000;71:87-94.

12. Lowenstein JM. Experiments with (-)hydroxycitrate. In: Burtley W, Kornberg HL, Quayle JR, eds. Essays in Cell Metabolism. New York: Wiley Interscience, 1970, 153-66.

13. Lunsford KE, Bodzin AS, Reino DC, et al. Dangerous dietary supplements: Garcinia cambogia associated hepatic failure requiring transplantation. World J Gastroenterol 2016;22:10071–6.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.