Nutritional Supplement

Garcinia cambogia

Also indexed as: Garcinia cambogia, HCA, Hydroxycut, Hydroxycitric Acid

(-)-Hydroxycitric acid (HCA) is a compound found in Garcinia cambogia, a type of fruit. HCA has a chemical structure similar to that of citric acid (the primary acid in citrus fruits).

References

1. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971;246:629-32.

2. Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357-63.

3. Cheema-Dhadli S, Harlperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem 1973;38:98-102.

4. Sullivan AC, Hamilton JG, Miller ON, et al. Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch Biochem Biophys 1972;150:183-90.

5. Greenwood MRC, Cleary MP, Gruen R, et al. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am J Physiol 1981;240:E72-8.

6. Sullivan AC, Triscari J. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr 1977;30:767-76.

7. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis. Lipids 1974;9:121-8.

8. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of(-)-hydroxycitrate upon the accumulation of lipid in the rat: II. Appetite. Lipids1974;9:129-34.

9. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitricacid) as a potential antiobesity agent: a randomized controlled trial. JAMA1998;280:1596-600.

10. Martinet A, Hostettmann K, Schultz Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine 1999;6:231-8.

11. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 2000;71:87-94.

12. Lowenstein JM. Experiments with (-)hydroxycitrate. In: Burtley W, Kornberg HL, Quayle JR, eds. Essays in Cell Metabolism. New York: Wiley Interscience, 1970, 153-66.

13. Lunsford KE, Bodzin AS, Reino DC, et al. Dangerous dietary supplements: Garcinia cambogia associated hepatic failure requiring transplantation. World J Gastroenterol 2016;22:10071–6.

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