Nutritional Supplement

Hyaluronic Acid

Possible Deficiencies

Hyaluronic acid is produced naturally in the human body and is not considered an essential nutrient. However, hyaluronic acid levels in osteoarthritic joints are below normal.21

Side Effects

A controlled study reported that males taking 600 mg per day of hyaluronic acid for four weeks had higher blood levels of the enzyme alkaline phosphatase.22 The significance of this finding is unclear.

There have been anecdotal reports of skin rash following oral supplementation with hyaluronic acid.23

References

1. Laurent TC, Fraser JR. Hyaluronan. FASEB J 1992;6:2397-404.

2. Anderson I. The properties of hyaluronan and its role in wound healing. Prof Nurse 2001;17:232-5 [review].

3. Taddeucci P, Pianigiani E, Colletta V, et al. An evaluation of Hyalofill-F plus compression bandaging in the treatment of chronic venous ulcers. J Wound Care 2004;13:202-4.

4. Soldati D, Rahm F, Pasche P. Mucosal wound healing after nasal surgery. A controlled clinical trial on the efficacy of hyaluronic acid containing cream. Drugs Exp Clin Res 1999;25:253-61.

5. Miller RS, Steward DL, Tami TA, et al. The clinical effects of hyaluronic acid ester nasal dressing (Merogel) on intranasal wound healing after functional endoscopic sinus surgery. Otolaryngol Head Neck Surg 2003;128:862-9.

6. Rivas Lacarte MP, Casasin T, Pumarola F, Alonso A. An alternative treatment for the reduction of tympanic membrane perforations: sodium hyaluronate. A double blind study. Acta Otolaryngol 1990;110:110-4.

7. Taddeucci P, Pianigiani E, Colletta V, et al. An evaluation of Hyalofill-F plus compression bandaging in the treatment of chronic venous ulcers. J Wound Care 2004;13:202-4.

8. Anderson I. The properties of hyaluronan and its role in wound healing. Prof Nurse 2001;17:232-5 [review].

9. Taddeucci P, Pianigiani E, Colletta V, et al. An evaluation of Hyalofill-F plus compression bandaging in the treatment of chronic venous ulcers. J Wound Care 2004;13:202-4.

10. Soldati D, Rahm F, Pasche P. Mucosal wound healing after nasal surgery. A controlled clinical trial on the efficacy of hyaluronic acid containing cream. Drugs Exp Clin Res 1999;25:253-61.

11. Miller RS, Steward DL, Tami TA, et al. The clinical effects of hyaluronic acid ester nasal dressing (Merogel) on intranasal wound healing after functional endoscopic sinus surgery. Otolaryngol Head Neck Surg 2003;128:862-9.

12. Rivas Lacarte MP, Casasin T, Pumarola F, Alonso A. An alternative treatment for the reduction of tympanic membrane perforations: sodium hyaluronate. A double blind study. Acta Otolaryngol 1990;110:110-4.

13. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dent Update 2002;29:144-8 [review].

14. Pistorius A, Martin M, Willershausen B, Rockmann P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int 2005;36:531-8.

15. Jentsch H, Pomowski R, Kundt G, Gocke R. Treatment of gingivitis with hyaluronan. J Clin Periodontol 2003;30:159-64.

16. Xu Y, Hofling K, Fimmers R, et al. Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2004;75:1114-8.

17. Tehranzadeh J, Booya F, Root J. Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol2005;46:288-96 [review].

18. Modawal A, Ferrer M, Choi HK, Castle JA. Hyaluronic acid injections relieve knee pain. J Fam Pract 2005;54:758-67 [review].

19. Bellamy N, Campbell J, Robinson V, et al . Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005;(2):CD005321 [review].

20. Arrich J, Piribauer F, Mad P, et al. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. CMAJ 2005;172:1039-43 [review].

21. Tehranzadeh J, Booya F, Root J. Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol2005;46:288-96 [review].

22. Bates B. Supplements trigger potassium, alkaline phosphatase changes. Skin and Allergy News 2003;July:43.

23. Sahelian R. Hyaluronic acid supplement side effects, benefit, allergy, toxicity, adverse events, and medical benefits for joint health information. [Cited 2006 May 13]. Available from URL: http://www.raysahelian.com/hyaluronic-acid.html.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.