Nutritional Supplement

Green Tea

Side Effects

Green tea is generally free of side effects. The most common adverse effects reported from consuming large amounts (several cups per day) of green tea are insomnia, anxiety, and other symptoms caused by the caffeine content in the herb.

An extract of green tea taken by healthy women with a meal inhibited the absorption of non-heme iron (e.g., the form of iron in plant foods) by 26%.72 Frequent use of green tea could, in theory, promote the development of iron deficiency in susceptible individuals.

There have been at least 34 case reports of people developing liver damage (sometimes severe) while consuming weight-loss products that contained concentrated extracts of green tea.73 A cause–effect relationship was not proven, and most of the products contained other ingredients in addition to green tea extract. However, researchers have concluded that green tea extract was the probable cause of liver damage in some of the cases.74 Scientists have cautioned against the use of large amounts, or concentrated extracts, of green tea.

Importantly, liver damage due to green tea extract and EGCG supplementation has been reported. A review of these reports indicates high doses (500–3,000 mg green tea extract or 250–1,800 mg of EGCG taken all at once daily) used for two weeks or longer and most often on an empty stomach are more likely to cause liver injury. While individual, possibly genetic, factors may increase susceptibility, it is suggested those with pre-existing liver disease and obesity may be at greatest risk.75

In addition, there is a case report in which a person developed thrombotic thrombocytopenic purpura (a condition in which a bruising develops as a result of a low platelet count) after consuming a weight-loss product that contained green tea extract for 2 months. Green tea was not proven to be the cause of this problem.76

References

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21. Ooshima T, Minami T, Aono W, et al. Reduction of dental plaque deposition in humans by oolong tea extract. Caries Res 1994;28:146-9.

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24. Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995;39:2375-7.

25. Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 1995;310:693-6.

26. Goto K, Kanaya S, Nishikawa T, et al. The influence of tea catechins on fecal flora of elderly residents in long-term care facilities. Ann Long-Term Care 1998;6:43-8.

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29. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res2006;66:1234-40.

30. Shanafelt TD, Lee YK, Call TG, et al. Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk Res 2006;30:707-12.

31. Marventano S, Salomone F, Godos J, et al. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr 2016;35:1269–81.

32. Yang C, Wang H, Sheridan Z. Studies on prevention of obesity, metabolic syndrome, diabetes, cardiovascular diseases and cancer by tea. J Food Drug Anal 2018;26:1–13.

33. Hibi M, Takase H, Iwasaki M, et al. Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials. Nutr Res 2018;55:1–10.

34. Li X, Wang W, Hou L, et al. Does tea extract supplementation benefit metabolic syndrome and obesity? A systematic review and meta-analysis. Clin Nutr 2019.

35. Casanova E, Salvado J, Crescenti A, Gibert-Ramos A. Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review. Int J Mol Sci 2019;20.

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37. Ferreira M, Silva D, de Morais A, et al. Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults - a review. Obes Rev 2016;17:1316–28.

38. Keske M, Ng H, Premilovac D, et al. Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate. Curr Med Chem 2015;22:59–69.

39. Quezada-Fernandez P, Trujillo-Quiros J, Pascoe-Gonzalez S, et al. Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Int J Food Sci Nutr 2019:1–9.

40. Liu K, Zhou R, Wang B, et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr 2013;98:340–8.

41. Yu J, Song P, Perry R, et al. The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis. Diabetes Metab J 2017;41:251–62.

42. Younes M, Aggett P, Aguilar F, et al. Scientific opinion on the safety of green tea catechins. EFSA Journal 2018;16:e05239.

43. Landini L, Rebelos E, Honka MJ. Green Tea from the Far East to the Drug Store: Focus on the Beneficial Cardiovascular Effects. Curr Pharm Des 2021;27:1931–40.

44. Xu R, Yang K, Li S, et al. Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr J 2020;19:48.

45. Asbaghi O, Fouladvand F, Moradi S, et al. Effect of green tea extract on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Metab Syndr 2020;14:293–301.

46. Yuan F, Dong H, Fang K, et al. Effects of green tea on lipid metabolism in overweight or obese people: A meta-analysis of randomized controlled trials. Mol Nutr Food Res 2018;62.

47. Momose Y, Maeda-Yamamoto M, Nabetani H. Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans. Int J Food Sci Nutr 2016;67:606–13.

48. Eng QY, Thanikachalam PV, Ramamurthy S. Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. J Ethnopharmacol 2018;210:296–310.

49. Tsubono Y, Tsugane S. Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women. Ann Epidemiol 1997;7:280-4.

50. Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 1995;310:693-6.

51. Rothenberg DO, Zhou C, Zhang L. A Review on the Weight-Loss Effects of Oxidized Tea Polyphenols. Molecules (Basel, Switzerland). 2018 May;23(5).

52. Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al. Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review Nutricion Hospitalaria. 2017 06;34(3):731–737.

53. Jurgens TM, Whelan AM, Killian L, et al. Green tea for weight loss and weight maintenance in overweight or obese adults. The Cochrane Database of Systematic Reviews. 2012 Dec;12:CD008650.

54. Huang J, Wang Y, Xie Z, et al. The anti-obesity effects of green tea in human intervention and basic molecular studies. European Journal of Clinical Nutrition. 2014 Oct;68(10):1075–87.

55. Okla M, Kim J, Koehler K, et al. Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis. Advances in Nutrition (Bethesda, Md.). 2017 May;8(3):473–483.

56. Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med 1992;21:334-50.

57. Kim J, Hwang JS, Cho YK, et al. Protective effects of (-)-epigallocatechin-3-gallate on UVA- and UVB-induced skin damage. Skin Pharmacol Appl Skin Physiol 2001;14:11-9.

58. Katiyar SK. Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Curr Drug Targets Immune Endocr Metabol Disord 2003;3:234-42 [review].

59. Katiyar SK, Perez A, Mukhtar H. Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Clin Cancer Res 2000;6:3864-9.

60. Elmets CA, Singh D, Tubesing K, et al. Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 2001;44:425-32.

61. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006;66:1234-40.

62. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Bioch 1995;22:169-80.

63. You SQ. Study on feasibility of Chinese green tea polyphenols (CTP) for preventing dental caries. Chin J Stom 1993;28(4):197-9.

64. Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995;39:2375-7.

65. Matsuo N, Yamada K, Shoji K, et al. Effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells: the structure-inhibitory activity relationship. Allergy 1997;52:58-64.

66. Plein K, Burkard G, Hotz J. Treatment of chronic diarrhea in Crohn disease. A pilot study of the clinical effect of tannin albuminate and ethacridine lactate. Fortschr Med 1993;111:114-8 [in German].

67. Li N, Sun Z, Han C, Chen J. The chemopreventive effects of tea on human oral precancerous mucosa lesions. Proc Soc Exp Biol Med 1999;220:218-24.

68. Ahn WS, Yoo J, Huh SW, et al. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev 2003;12:383-90.

69. Murray MT. The Healing Power of Herbs. Rocklin, CA: Prima Publishing, 1995, 192-6.

70. Imai K, Suga K, Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 1997;26:769-75.

71. Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 1995;310:693-6.

72. Samman S, Sandstrom B, Toft MB, et al. Green tea or rosemary extract added to foods reduces nonheme-iron absorption. Am J Clin Nutr 2001;73:607-12.

73. Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 2006;144:68-71.

74. Schonthal AH. Adverse effects of concentrated green tea extracts. Mol Nutr Food Res 2011;55:874-885.

75. Oketch-Rabah HA, Roe AL, Rider CV, et al. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicol Rep 2020;7:386–402.

76. Liatsos GD, Moulakakis A, Ketikoglou I, Klonari S. Possible green tea-induced thrombotic thrombocytopenic purpura. Am J Health Syst Pharm 2010;67:531-4.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.