Nutritional Supplement

Glycine

  • Negative Interactions

    1
    • Glycine

      Clozapine

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      The use of glycine may interfere with the efficacy of clozapine as an antipsychotic drug. In a double-blind trial, people with chronic, treatment-resistant schizophrenia were given clozapine (400–1,200 mg per day) and either glycine (30 g per day) or placebo for 12 weeks. The combination of clozapine and glycine was not effective at decreasing symptoms. In contrast, participants who took clozapine without glycine had a 35% reduction in some symptoms. Therefore, the combination should be avoided until more is known.

      Clozapine
      Glycine
      ×
      1. Potkin SG, Jin Y, Bunney BG, et al. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.
  • Supportive Interactions

    17
    • Glycine

      Asenapine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Asenapine
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Clozapine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Clozapine
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Haloperidol

      Support Medicine

      Two double-blind studies have found that 0.4–0.8 mg/kg body weight per day of glycine can reduce the so-called negative symptoms of schizophrenia when combined with haloperidol and related drugs. Negative symptoms include reduced emotional expression or general activity. The action of glycine in combination with the drugs was greater than the drugs alone, suggesting a synergistic action. Another double-blind study using approximately half the amount in the positive studies could not find any benefit from adding glycine to antipsychotic drug therapy. Patients with low blood levels of glycine appeared to improve the most when given glycine in addition to their antipsychotic drugs. No side effects were noticed in these studies, even when more than 30 grams of glycine were given daily.

      Haloperidol
      Glycine
      ×
      1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 1996;169:610-7.
      2. Javitt DC, Zylberman I, Zukin SR, et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry 1994;151:1234-6.
      3. Potkin SG, Costa J, Roy S, et al. Glycine in treatment of schizophreniaβ€”theory and preliminary results. In: Meltzer HY (ed). Novel Antipsychotic Drugs. New York: Raven Press, 1990:179-88.
    • Glycine

      Iloperidone

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Iloperidone
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Lurasidone

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Lurasidone
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Olanzapine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with olanzapine experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Olanzapine
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Olanzapine Pamoate

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with olanzapine experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Olanzapine Pamoate
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Olanzapine-Samidorphan

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Olanzapine-Samidorphan
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Paliperidone

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Paliperidone
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Paliperidone Palm (3-Month)

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Paliperidone Palm (3-Month)
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Paliperidone Palm (6-Month)

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Paliperidone Palm (6-Month)
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Paliperidone Palmitate

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Paliperidone Palmitate
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Quetiapine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Quetiapine
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Risperidone

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Risperidone
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Risperidone Microspheres

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Risperidone Microspheres
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Ziprasidone

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Ziprasidone
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Glycine

      Ziprasidone Mesylate

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Ziprasidone Mesylate
      Glycine
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.

References

1. Waziri R. Glycine therapy of schizophrenia: Some caveats. Biol Psychiatry 1996;39:155-6.

2. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.

3. Evins AE, Fitzgerald SM, Wine L, et al. Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry 2000;157:826-8.

4. Potkin SG, Jin Y, Bunney BG, et al. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.

5. Heresco-Levy U, Javitt DC, Ermilov M, et al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 1996;169:610-7.

6. Javitt DC, Zylberman I, Zukin SR, et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry 1994;151:1234-6.

7. Semba J. [Glycine therapy of schizophrenia; its rationale and a review of clinical trials]. Nihon Shinkei Seishin Yakurigaku Zasshi 1998;18:71-80 [review] [in Japanese].

8. Rosse RB, Theut SK, Banay-Schwartz M, et al. Glycine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label, pilot study. Clin Neuropharmacol 1989;12:416-24.

Copyright Β© 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.