Nutritional Supplement

Chaparral

Side Effects

There have been sporadic reports of people developing liver or kidney problems after taking chaparral, particularly in capsules.13 Almost all of these cases involved either the use of capsules or excessive amounts of tea. Some of these cases were people with established liver disease prior to using the herb. Tea and tincture of chaparral have an extremely strong taste considered disagreeable by most people, which restricts the amount they can tolerate before feeling nauseous. Capsules bypass this protective mechanism and should therefore be avoided. Since human studies have shown that large amounts of chaparral tea and injections of NDGA in people with cancer do not cause liver or kidney problems,14 it is likely the cases of toxicity represented individual reactions.15

References

1. Birkenfeld S, Zaltsman YA, Krispin M, et al. Antitumor effects of inhibitors of arachadonic acid cascade on experimentally induced intestinal tumors. Dis Colon Rectum 1987;30:43-6.

2. Smart CR, Hogle CR, Vogel H, et al. Clinical experience with nordihydroguaiaretic acid—”chapparel tea” [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39-43.

3. Bokoch G, Reed P. Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes. J Biol Chem 1981;256:4156.

4. Salari H, Braquet P, Borgeat P. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. Prostaglan Leukot Med 1984;13:53-60.

5. Calzado-Flores C, Segura-Luna JJ, Guajardo-Touche EM. Effects of chaparrin, nordihydroguaiaretic acid and their structural analogues on Entamoeba histolytica cultures. Proc West Pharmacol Soc 1995;38:105-6.

6. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

7. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

8. Brinker F. Larrea tridentata (D.C.) Coville (chaparral or creosote bush). Br J Phytother 1993/1994;3:10-31 [review].

9. Moore M. Medicinal Plants of the Desert and Canyon West. Santa Fe: Museum of New Mexico Press, 1989, 27-9.

10. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

11. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

12. Moore M. Medicinal Plants of the Desert and Canyon West. Santa Fe: Museum of New Mexico Press, 1989, 27-9.

13. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Int Med 1997;157:913-9.

14. Smart CR, Hogle CR, Vogel H, et al. Clinical experience with nordihydroguaiaretic acid—”chapparel tea” [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39-43.

15. McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 67.

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.