Nutritional Supplement

Carnosine

Also indexed as: L-Carnosine

  • Digestive Support

    Peptic Ulcer

    Studies have shown that a zinc salt of the amino acid carnosine protects against ulcer formation and promotes the healing of existing ulcers.
    Peptic Ulcer
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    Experimental animal studies have shown that a zinc salt of the amino acid carnosine exerts significant protection against ulcer formation and promotes the healing of existing ulcers.3,4 However, because zinc by itself has been shown to be helpful against peptic ulcer, it is not known how much of the beneficial effect was due to the carnosine.5,6 Clinical studies in humans demonstrated that this compound can help eradicate H. pylori, an organism that has been linked to peptic ulcer and stomach cancer.7 The amount of the zinc carnosine complex used in research studies for eradication of H. pylori is 150 mg twice daily.

    Peptic Ulcer

    Carnisone may protect against ulcer formation and promote the healing of existing ulcers.
    Peptic Ulcer
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    Experimental animal studies have shown that a zinc salt of the amino acid carnosine exerts significant protection against ulcer formation and promotes the healing of existing ulcers.8,9 However, because zinc by itself has been shown to be helpful against peptic ulcer, it is not known how much of the beneficial effect was due to the carnosine.10,11 Clinical studies in humans demonstrated that this compound can help eradicate H. pylori, an organism that has been linked to peptic ulcer and stomach cancer.12 The amount of the zinc carnosine complex used in research studies for eradication of H. pylori is 150 mg twice daily.

  • Pain Management

    Wound Healing

    Carnosine, a small molecule composed of the amino acids histidine and alanine, appears to promote wound healing.
    Wound Healing
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    Carnosine is a small molecule composed of the amino acids histidine and alanine. The exact biological role of carnosine is not completely understood, but animal research demonstrates that it promotes wound healing.13 More research is warranted in this area.

  • Skin Protection

    Wound Healing

    Carnosine, a small molecule composed of the amino acids histidine and alanine, appears to promote wound healing.
    Wound Healing
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    Carnosine is a small molecule composed of the amino acids histidine and alanine. The exact biological role of carnosine is not completely understood, but animal research demonstrates that it promotes wound healing.14 More research is warranted in this area.

What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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References

1. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med 1992;13:379-444.

2. Bonfanti L, Peretto P, De Marchis S, Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 1999;59:333-53.

3. Nishiwaki H, Kato S, Sugamoto S, et al. Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc. J Physiol Pharmacol 1999;50:183-95.

4. Arakawa T, Satoh H, Nakamura A, et al. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci 1990;35:559-66.

5. Cho CH, Ogle CW. A correlative study of the antiulcer effects of zinc sulphate in stressed rats. Eur J Pharmacol 1978;48:97-105.

6. Frommer DJ. The healing of gastric ulcers by zinc sulphate. Med J Aust 1975;22(21):793-6.

7. Kashimura H, Suzuki K, Hassan M, et al. Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxicillin, and clarithromycin increases the cure rate of Helicobacter pylori infection. Aliment Pharmacol Ther 1999;13(4):483-7.

8. Nishiwaki H, Kato S, Sugamoto S, et al. Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc. J Physiol Pharmacol 1999;50:183-95.

9. Arakawa T, Satoh H, Nakamura A, et al. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci 1990;35:559-66.

10. Cho CH, Ogle CW. A correlative study of the antiulcer effects of zinc sulphate in stressed rats. Eur J Pharmacol 1978;48:97-105.

11. Frommer DJ. The healing of gastric ulcers by zinc sulphate. Med J Aust 1975;22(21):793-6.

12. Kashimura H, Suzuki K, Hassan M, et al. Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxicillin, and clarithromycin increases the cure rate of Helicobacter pylori infection. Aliment Pharmacol Ther 1999;13(4):483-7.

13. Roberts PR, Black KW, Santamauro JT, Zaloga GP. Dietary peptides improve wound healing following surgery. Nutrition 1998;14;266-9.

14. Roberts PR, Black KW, Santamauro JT, Zaloga GP. Dietary peptides improve wound healing following surgery. Nutrition 1998;14;266-9.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.