Nutritional Supplement

7-KETO for Weight Control

Also indexed as: 7-KETO
7-Keto DHEA

  • Weight Management

    Obesity

    7-Keto DHEA was found in a single randomized controlled trial to promote weight loss in people with overweight and obesity.
    Obesity
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    7-Keto DHEA (3-acetyl-7-oxo-dehydroepiandrosterone) is a derivative of DHEA that may influence hormone signaling related to fat production and distribution.3 7-Keto DHEA was found to promote weight loss in in one double-blind placebo-controlled trial. The trial included 30 participants with overweight or obesity who engaged in a cross-training exercise program for 60 minutes three times per week, were instructed to eat a diet providing 1,800-calories per day, and were given either 100 mg of 7-keto DHEA or placebo twice daily. After eight weeks, those receiving 7-keto DHEA had lost more weight and lowered their percentage of body fat more than those taking a placebo. In addition, they had increased levels of active thyroid hormone (triiodothyronine or T3), which plays a major role in determining metabolic rate.4
What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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References

1. Lardy H, Kneer N, Wei Y, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids 1998;63:158-65.

2. Kalman DS, Colker CM, Swain MA, et al. A randomized, double-blind, placebo controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Ther Res 2000;61:435-42.

3. Sedláčková B, Dušátková L, Zamrazilová H, et al. 7-oxygenated derivatives of dehydroepiandrosterone and obesity. Prague Med Rep 2012 ;113(2):147–55.

4. Schirmer MA, Phinney SD. Gamma-linolenate reduces weight regain in formerly obese humans. J Nutr 2007;137:1430-35.

5. Lardy H, Kneer N, Wei Y, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids 1998;63:158-65.

6. Davidson MH, Weeks CE, Lardy H, et al. Safety and endocrine effects of 3-acetyl-7-oxo DHEA (7-keto DHEA). FASEB J 1998;12:A4429.

7. Lardy H, Henwood SM, Weeks CE. An acute oral gavage study of 3beta-acetoxyandrost- 5-ene-7,17-dione (7-oxo-DHEA-acetate) in rats. Biochem Biophys Res Commun 1999;254:120-3.

8. Henwood SM, Weeks CE, Lardy H. An escalating dose oral gavage study of 3beta-acetoxyandrost-5-ene-7, 17-dione (7-oxo-DHEA-acetate) in rhesus monkeys. Biochem Biophys Res Commun 1999;254:124-6.

9. Weeks C, Lardy H, Henwood S. Preclinical toxicology evaluation of 3-acetyl-7-oxo-dehydroepiandrosterone (7-keto DHEA). FASEB J 1998;12:A4428.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.