Nutritional Supplement

Yohimbe

Also indexed as: Pausinystalia yohimbe

  • Negative Interactions

    1

    • Yohimbe

      Brimonidine

      Reduces Effectiveness

      The active ingredients in yohimbine can block the actions of brimonidine in certain human tissues, thus reducing the drug’s beneficial effects. Adequate human studies involving the eye are lacking, and until more information is available, yohimbine should be avoided in people using brimonidine.

      Brimonidine
      Yohimbe
      ×
      1. Berlan M, LeVerge R, Galitzky J, LeCorre P. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol 1993;108:927-32.

  • Supportive Interactions

    2

    • Yohimbe

      Bupropion

      Support Medicine

      A 50-year-old woman who was unresponsive to traditional antidepressant therapy was reported to have a marked and persistent improvement in mood when yohimbine was added to her bupropion therapy. Further research is necessary to determine the significance of this finding.

      Bupropion
      Yohimbe
      ×
      1. Pollack MH, Hamerness P. Adjunctive yohimbine for treatment in refractory depression. Biol Psychiatry 1993;33:220-1.

    • Yohimbe

      Fluvoxamine

      Support Medicine

      The alkaloid yohimbine (Pausinystalia yohimbe) from the African yohimbe tree affects the nervous system in a way that may complement fluvoxamine. One report studied depressed people who had not responded to fluvoxamine. When 5 mg of yohimbine was added three times each day, there was significant improvement. Some people required higher amounts of yohimbine before their depression improved. Because yohimbine can have side effects, it should only be taken under a doctor’s supervision. Yohimbine is a prescription drug, but standardized extracts of yohimbe that contain yohimbine are available as a supplement.

References

1. Riley AJ. Yohimbine in the treatment of erectile disorder. Br J Clin Pract 1994;48:133-6.

2. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

3. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

4. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

5. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

6. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

7. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

8. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

9. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

10. Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998;159:433-6.

11. Carey MP, Johnson BT. Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations. Arch Sex Behav 1996;25:341.

12. Kunelius P, Häkkinen J, Lukkarinen O. Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study. Urol 1997;49:441-4.

13. Mann K, Klingler T, Noe S, et al. Effect of yohimbine on sexual experiences and nocturnal tumescence and rigidity in erectile dysfunction. Arch Sex Behav 1996;25:1-16.

14. Kucio C, Jonderko K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci 1991;27:550–6.

15. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

16. Swann AC, Lijffijt M, Lane SD, et al. Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology (Berl) 2013 Sep;229(1):83–94.

17. Mosqueda-Garcia R, Fernandez-Violante R, Tank J, et al. Yohimbine in neurally mediated syncope. Pathophysiological implications. J Clin Invest 1998;102:1824-30.

18. Goldberg MR, Robertson D. Yohimbine: a pharmacological probe for the study of the alpha 2-adrenoceptor. Pharmacol Rev 1983;35:143-180

19. Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988;18:587-94.

20. Zahorska-Markiewicz B, Kucio C, Piskorska D. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res 1986;18:693-7.

21. Waluga M, Janusz M, Karpel E, et al. Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women. Clin Physiol 1998;18:69-76.

22. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

23. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

24. Duke J. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 351.

25. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

26. Drug Facts and Comparisons. St. Louis: Facts and Comparisons, 1998, 3659.

27. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 382-3.

28. Goldberg KA. Yohimbine in the treatment of male erectile sexual dysfunction—a clinical review. Today's Ther Trends J New Dev Clin Med 1996;14:25-33.

29. Friesen K, Palatnick W, Tenenbein M. Benign course after massive ingestion of yohimbine. J Emerg Med 1993;11:287-8.

30. Bremner JD, Innis RB, Ng CK, et al. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1997;54:246-54.

31. Charney DS, Woods SW, Goodman WK, Heninger GR. Neurobiological mechanisms of panic anxiety: Biochemical and behavioral correlates of yohimbine-induced panic attacks. Am J Psychiatry 1987;144:1030-6.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.