Nutritional Supplement

Pau D’arco

Parts Used & Where Grown

Various related species of pau d’arco trees grow in rain forests throughout Latin America. The bark is used for medical purposes.

How It Works

Lapachol and beta-lapachone (known collectively as naphthaquinones) are two primary active compounds in pau d’arco. According to laboratory tests, both have anti-fungal properties as potent as ketoconazole, a common antifungal drug.1 However, amounts of these constituents needed to exert an antifungal effect may be toxic to humans. Although these compounds also have anticancer properties according to test tube studies, the effective amount for this effect may also be toxic.2,3 Therefore, pau d’arco cannot currently be recommended as a treatment for cancer.

References

1. Guiraud P, Steiman R, Campos-Takaki GM, et al. Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta Med 1994;60:373-4.

2. Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton, NY: Pharmaceutical Products Press, 1994, 180.

3. Oswald EH. Lapacho. Br J Phytother 1993/4;3:112-7.

4. Pizzorno JE, Murray MT. A Textbook of Natural Medicine, 2nd ed.. New York: Churchill Livingstone, 1999, 968.

5. Anesini C, Perez C. Screening of plants used in Argentine folk medicine for antimicrobial activity. J Ethnopharmacol 1993;39:119-28.

6. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 470-1.

7. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 70-1.

8. Awang DVC, Dawson BA, Ethier JC, et al. Naphthoquinone constituents of commercial lapacho/pau d'arco/taheebo products. J Herbs Spices Med Plants 1994;2:27-43.

9. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 470-1.

10. Oswald EH. Lapacho. Br J Phytother 1993/4;3:112-7.

11. Hullar TE, Sapers BL, Ridker PM, et al. Herbal toxicity and fatal hepatic failure [letter]. Am J Med 1999;106:267-8.

12. Brown D. A case of fatal liver failure associated with herbal products. Healthnotes Rev Complement Integrative Med 1999;6:176-7.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.