Health Condition

Immune Function

  • Humidifiers & Vaporizers

    People use air humidifiers for a variety of reasons, such as to soothe dry sinuses, to relieve symptoms of a cold or sinus infection, and to minimize dry skin and chapped lips during dry winter months. As you choose an air humidifier, keep the following in mind:

    • Health insurance may cover the cost, or you may be able to use a health savings account to pay for a humidifier, especially if needed for a specific health condition such as asthma. Call your insurance provider to find out before your purchase.
    • Consider your intended use to help you select the best model for your needs. How big is the room you want to humidify? Is noise an issue?
    • A unit that is easy to clean may help minimize the risk of mold problems.
    • Some manufacturers overestimate the square footage covered by a given model; if in doubt, you may want to try a larger unit.
    • Inquire about limitations on use. For example, some humidifiers will not operate properly with very hard or very soft water.
    • Consider additional costs of using the product, such as replacement filters, distilled water, or cleaning solutions.
    • Evaluate capacity and operating time, which will depend upon the size of the water reservoir.
    • Consider extras you may or may not want, such as automatic shut off, timer features, and 360-degree dispersal of humidified air.
    • Ask about the warranty and which components are covered.
    • Evaporative Cool Mist

      What they are: Evaporative humidifiers work by drawing dry air into the unit and then over a moistened wick or other material. The moistened air is dispersed back into the room.

      Why to buy: This type of machine has the capacity to humidify large areas. Evaporative models are the least expensive type of humidifier to purchase and operate, and they don’t require expensive filters.

      Things to consider: Evaporative units tend to be noisier, require more frequent cleaning than other humidifiers, and cannot raise humidity above 40% to 50%. Wicks may need to be replaced periodically, though wicks tend to be less expensive than the filters required in other models.

    • Ultrasonic Warm/Cold Mist

      What they are: Ultrasonic humidifiers use a thin, rapidly vibrating metal plate or diaphragm to create tiny water particles, which generates a mist. The mist is pushed into the room with a fan. Some units have the option of heating the water before it hits the vibrating plate.

      Why to buy: Ultrasonic models are quiet and easy to clean, and warm mist can raise humidity faster than cold mist or evaporative humidifiers. A warm mist option may be preferable in cold climates. There is no limit to the amount of humidity that can be added to the air.

      Things to consider: These units are more expensive than evaporative humidifiers, and most require replacement filters and demineralization cassettes, which increase operation costs. Ultrasonic models humidify a smaller area than similarly sized evaporative humidifiers, and must be placed several feet off the floor for optimal functioning.

  • Nasal Sprays

    If you suffer from nasal and sinus problems, you’re not alone. About 30 million American adults suffer at least one bout of sinusitis—inflammation of the nasal passages and sinuses—each year. Fortunately, a wide range of products is available to manage nasal and sinus irritations, and this guide will help you find a nasal spray product to fit your health needs, lifestyle, and budget. Keep the following in mind as you choose a nasal spray:

    • Many minor nasal and sinus problems can be treated at home with over-the counter products. However, call your doctor if you experience persistent and severe sinus pain, if you have a fever lasting more than a day, if you experience tooth and dental pain, or if you have yellow, green, or bloody nasal discharge. These symptoms may signal a more serious health problem.
    • If you are managing a health condition, consider your medications when selecting a nasal spray. Consult your doctor or pharmacist about your safest options.
    • Use over-the-counter and prescription nasal sprays according to package directions and compare ingredients to avoid accidentally taking two medications together that contain the same active ingredients.
    • Over-the-counter decongestant nasal sprays work best when taken occasionally, for a few days at a time. When taken long-term, these medications can lose their effectiveness and may even worsen symptoms.
    • Decongestant Nasal Sprays

      What they are: Over-the-counter decongestant nasal sprays contain oxymetazoline, phenylephrine, xylometazoline, or naphazoline, which are medications that open up nasal passages by constricting blood vessels in the lining of the nose.

      Why to buy: These products offer quick relief from nasal and sinus congestion, they are available at any pharmacy, and they are relatively inexpensive.

      Things to consider: Decongestant nasal sprays should not be taken for more than five days at a time. Use for more than a few days can lead to a worsening of symptoms, a condition called rebound effect or rhinitis medicamentosa. Do not use these products without consulting your doctor if you have high blood pressure, heart disease or irregular heart beats, thyroid problems, diabetes, glaucoma or increased pressure in the eye, an enlarged prostate or difficulty urinating, liver disease, kidney disease, or are taking a MAOI (monoamine oxidase inhibitor) medication.

    • Saline Nasal Sprays

      What they are: Saline nasal sprays are a mild salt water solution used to flush out the sinuses and rinse away mucus, allergens, and other debris that can irritate the nasal lining and sinuses. Saline rinses using a neti pot or other irrigation systems are another alternative.

      Why to buy: These products may be helpful for people with seasonal allergies, dry nasal passages, or thick mucus due to a cold or sinus infection. Rinsing away allergens, bacteria, and other irritants may lessen symptoms.

      Things to consider: Saline nasal sprays are available over the counter and are safe and easy to use. If you are trying to limit your use of decongestant nasal sprays to avoid rebound effect, saline sprays may be a good option.

    • Natural & Homeopathic Nasal Sprays

      What they are: Natural and homeopathic nasal sprays often use a saline solution as a base and contain added natural ingredients, such as capsaicin to ease pain and inflammation, nettle for allergies, peppermint to clear sinuses, feverfew for headaches, and zinc for colds.

      Why to buy: Some of the individual ingredients in natural nasal sprays are research-proven to help specific symptoms when taken orally or applied topically, such as nettle for allergies, feverfew for headaches, and capsaicin for pain. Most are not well studied for use in nasal sprays, but are generally considered safe when used as directed. They may provide more relief than saline spray alone.

      Things to consider: Most of the herbs and other ingredients in natural nasal sprays have a good track record of safety, but zinc nasal sprays have caused permanent loss of smell in some people and all of these substances may potentially interact with medications. If in doubt, ask your doctor or pharmacist if these products are safe for you, especially if you regularly use other over-the-counter or prescription medications.

    • Antihistamine Nasal Sprays

      What they are: Antihistamine nasal sprays are available by prescription only and contain medications which lessen nasal and sinus allergy symptoms.

      Why to buy: If you have seasonal allergies or hay fever that cause significant discomfort and that are not well managed with other medications or lifestyle changes, an antihistamine nasal spray may be a good option.

      Things to consider: These products alleviate nasal and sinus symptoms related to allergies. They will not lessen symptoms of a cold or other non-allergy symptoms. Antihistamine nasal sprays can cause drowsiness, fatigue, and nosebleeds in a small percentage of people who use them.

    • Corticosteroid Nasal Sprays

      What they are: Corticosteroid nasal sprays are available by prescription only and contain medications to lessen sinus inflammation and pain due to a variety of causes.

      Why to buy: Corticosteroid nasal sprays often are used to manage nasal and sinus symptoms due to allergies, but can reduce inflammation due to other causes as well. If you have chronic sinusitis, these products may be a good option for you.

      Things to consider: Symptoms often return when corticosteroid nasal sprays are stopped, so they may be prescribed for years. To date, no studies have identified health risks linked to long-term use. Corticosteroid nasal sprays can cause burning, dryness, irritation and itching in the nose and throat, nosebleeds, runny nose, headaches or upset stomach in some people.

  • Cold & Flu Medicines

    The common cold and influenza are top of mind during back-to-school and winter seasons, but they can actually strike at any time. Stock your medicine cabinet with relief products so you’re prepared when cold and flu germs strike. As you choose an over-the-counter (OTC) cold or flu medicine, keep the following in mind:

    • Most cold, cough, and flu remedies have expiration dates, so periodically check the bottles in your medicine cabinet and restock when needed.
    • If symptoms persist for several days and do not improve with the use of OTC medications and aids, contact your doctor. You may have an infection that requires antibiotics or other medical intervention. It’s best to err on the side of caution, especially with small children and seniors.
    • Many cold and flu medications are not appropriate for all ages, so check labels carefully.
    • Adult Cold, Cough & Flu Remedies

      What they are: Most cold and flu remedies use the same active ingredients and are formulated for common symptom combinations: These might include a nasal decongestant, a pain reliever-fever reducer (most use acetaminophen), an antihistamine (to help with sneezing and runny nose), and a cough suppressant. Soothing throat drops often contain a cough suppressant such as menthol, and cough syrups have an expectorant such as guaifenesin to ease chest congestion.

      Why to buy: Formulated to provide quick and effective relief, cold and flu products are available in a wide variety of easy-to-take forms, from tablets and capsules to liquids and nasal sprays. Look for variations for night-time or day-time use and long-term release formulas.

      Things to consider: Decongestants may lead to wakefulness, antihistamines and alcohol may cause drowsiness. Phenylephrine, a common decongestant, may increase blood pressure so read labels carefully if you have heart concerns. And remember: not all medications play well together so use care if you plan to combine products.

    • Children’s Cold, Cough, & Flu

      What they are:Similar to adult cold and flu remedies, kid-friendly versions are formulated with ingredients in lower dosage amounts.

      Why to buy: When your child is miserable with the cold or flu, many parents are looking for ways to quickly ease symptoms. Children’s products are safe and easy to take—and a spoonful of sugar won’t be needed to get their medicine to go down, as most are available in fun, fruity flavors.

      Things to consider: Read labels carefully and don’t exceed recommended dosage amounts. Many children’s formulas contain sugar and flavors to make them taste better, so make certain you store medications out of reach so the kids don’t help themselves. If you have a child under age two, take extra care to make sure you are only using recommended medicines.

    • Sore Throat Relief

      What they are: Lozenges and sprays contain soothing and numbing ingredients to ease your pain. Cold products containing aspirin or other pain relievers may also help.

      Why to buy: Scratchy, sore, or painful throats deserve quick relief. Choose products enhanced with vitamin C or zinc, known for their immune-supporting power.

      Things to consider: Most cough and throat drops are available sugar-free, ideal for people with diabetes or those avoiding sugar (always a good idea when you’re sick). Pay attention to ingredients as some cough and throat syrups contain alcohol which may cause drowsiness.

    • Fever & Pain Reducers

      What they are: Fever and pain reducers are available in a variety of formats, from liquids to tablets, to help prevent the body from overheating and feeling the discomfort of aches and pains. Many fever and pain reducers are nonsteroidal anti-inflamatory drugs (NSAIDs).

      Why to buy: Running a fever can be miserable, but several over-the-counter options may help you manage:

      • Ibuprofen (NSAID): A proven fever reducer, also good for pain relief and reducing inflammation, ibuprofen is usually less irritating to the stomach than aspirin (although drinking alcohol can increase the chances of stomach issues).
      • Aspirin (NSAID): Used to combat fever and pains associated with common cold for decades, aspirin is known to offer sustained fever relief and help alleviate achiness, discomfort, headache, and sore throat pain. Effervescent aspirin has been shown to alleviate pain faster than tablets.
      • Naproxen (NSAID): Naproxen can be harder on the stomach, however, it’s a proven pain reliever and fever reducer, known to provide longer relief on a single dose and to offer the smallest overall cardiac risks of all NSAIDs.
      • Acetaminophen: A pain reliever and fever reducer used in many cold and flu products, and approved for use in all ages, it’s easy on the stomach, though it may carry some risk of liver issues, especially when combined with alcohol use.

      Things to consider: Pay attention when using nonsteroidal anti-inflammatory drugs (NSAIDs), as you should only take one at a time, and they can have a negative impact on heart health (except for aspirin at a low dose). Do not give ibuprofen or aspirin to children or teens with a fever, due to risk of Reye’s Syndrome. As with any medication, read labels carefully and don’t exceed the recommended dosage unless directed by a doctor.

  • Fever Reducers

    Fevers help our bodies battle infections, such as a cold and flu, but if the temperature goes too high, it can worsen symptoms or cause other adverse effects. In many cases, fever may be managed at home using an over-the-counter fever reducer, but not every product is right for every situation.

    There are three types of fever reducers: nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and specialty fever reducers. Read our guide for a quick overview on maximizing benefits and minimizing risks of using these products. Keep the following in mind as you choose a fever reducer:

    • If you or a family member has a high fever—103°F and up for kids and 102°F or above for adults—call your doctor.
    • Call your doctor right away if a fever is accompanied by breathing trouble, bluish skin color, irritability, difficulty waking up, confusion, disorientation, seizures, continued vomiting, abdominal pain, pain or pressure in the chest, or swollen neck or jaw glands.
    • Compare ingredients to avoid accidentally taking two medications together that contain the same active ingredients.
    • If you are using more than one product at a time, check with your doctor about which fever reducers are okay to take together and how best to avoid mixing drugs that should not be combined.
    • If you are managing a health condition, consider the medications you use before selecting an additional product. Consult your doctor or pharmacist if you are unsure about whether any particular fever reducer is safe for you.
    • If your fever is not accompanied by other symptoms, such as a cough, runny nose, or chest congestion, treat only for a fever.
    • Read labels and select the best product for daytime or nighttime needs, depending on when you plan to take it.
    • Take your fever reducer with plenty of fluids; good hydration is vital to at-home fever management.
    • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

      What they are: Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin ibuprofen, and naproxen. NSAIDs block the production of prostaglandins, substances made by the body that cause fever.

      Why to buy: NSAIDs effectively lower a fever, can lessen muscle aches and pains that accompany a cold or flu, and are available as brand name and generic products. Generics typically cost less. NSAIDs come as tablets, soft gels, or caplets, and ibuprofen comes in a chewable children’s form. Some NSAIDs are available in powdered drink formula, in combination with other ingredients, which are designed to address a variety of cold and flu symptoms in addition to fever.

      Things to consider: Non-aspirin NSAIDs (ibuprofen, naproxen) slightly increase the risk of heart attack, while aspirin decreases heart attack risk. If you have existing heart disease, or if you already take daily aspirin to lower heart attack risk, consult your physician before using ibuprofen, naproxen, or additional aspirin. All NSAIDs can increase the risk of bleeding and may cause stomach or duodenal ulcers in some people. Those with sensitive stomachs may want to try acetaminophen instead. Never use aspirin to treat children or teens.

    • Acetaminophen

      What it is: Acetaminophen is a non-NSAID fever reducer, which also can be used to manage headaches, toothaches, muscular and joint pain, menstrual cramps, and pain due to cold and flu.

      Why to buy: Acetaminophen often is used instead of an NSAID, because it does not increase the risk of heart attack or bleeding and it is safe for children and teens. Acetaminophen can be found in tablet, soft gel, caplet, and children’s chewable form. Some powdered drink formulas contain acetaminophen in combination with other ingredients, which are designed to address a variety of cold and flu symptoms in addition to fever.

      Things to consider: Use caution with acetaminophen and alcohol; this combination can harm the liver. Acetaminophen may not be right for people with liver disease or abnormal liver function, and excessive doses can damage the liver.

    • Specialty Fever Reducers

      What they are: Specialty fever reducers contain NSAIDs or acetaminophen, plus other ingredients to treat a particular issue.

      Why to buy: People use specialty fever reducers when they have a cold or flu and need relief from additional symptoms. Cold and flu products that reduce fever may also contain pseudoephedrine to manage sinus pain, dextromethorphan to quiet a cough, or guaifenesin to loosen congestion.

      Things to consider: These products contain the same ingredients as regular fever reducers—either NSAIDs or acetaminophen—so the same cautions with use apply. Additionally, you may need to avoid certain other ingredients in these products. Consult your doctor if you are unsure. Specialty fever reducers that contain aspirin are not safe for children or teens. If you need help selecting an appropriate product for your child, ask your pediatrician.

  • Sleep Aids

    Characterized by difficulty falling asleep, waking up often, and poor-quality sleep, insomnia can take a toll on health and leave a person exhausted and cranky. If you have trouble sleeping, an occasional over-the-counter sleep aid may help you get the sleep you need. This buying guide will help you find a sleep aid to fit your health goals, lifestyle, and budget. Keep the following additional points in mind as you choose a product:

    • Everyone has a sleepless night here or there, but if persistent insomnia is new for you, talk to your doctor. It may signal a more serious health problem.
    • When selecting a product, consider medications you use and health conditions you have. Consult your doctor or pharmacist if unsure about whether any particular sleep aid is safe for you.
    • If you have a history of mental health conditions, such as anxiety or depression, do not use sleep aids without first discussing it with your doctor. Some of these products may intensify mental health issues and many can interfere with medications used to manage mental health issues.
    • Use sleep aids carefully, follow all package directions, and always compare ingredients to avoid accidentally taking two medications together that contain the same active ingredients.
    • Do not use sleep aids and alcohol together. Alcohol increases the sedative effects of over-the-counter sleep medications; combining the two can lead to dizziness or fainting.
    • Over-the-counter medications work best when taken occasionally. When taken long-term, these medications can lose their effectiveness and also cause some dependency.
    • Over-the-Counter Medications

      What they are: There are two over-the-counter medications approved for use as sleep aids to manage occasional insomnia:

      • Diphenhydramine. The active ingredient in the antihistamine Benadryl, this medication also is found in brand name sleep aids such as Tylenol PM and Sominex, as well as numerous generic sleep aids.
      • Doxylamine. The active ingredient in Unisom, doxylamine also is found in generic sleep aids.

      Why to buy: Diphenhydramine and doxylamine effectively induce drowsiness and lead to uninterrupted sleep for many people. These products come in many forms, including soft gels, tablets, caplets, and chewables. Soft gels and chewables are faster acting than tablets.

      Things to consider: You should not take diphenhydramine or doxylamine if you are pregnant or breast-feeding, or if you have glaucoma, heart problems, enlarged prostate, or ulcers. Additionally, do not take doxylamine if you have or have had asthma or bronchitis. Some people feel groggy the next day after taking these medications. For very few people, especially children, diphenhydramine and doxylamine may cause agitation and alertness, which will not help insomnia!

    • Herbs, Dietary Supplements, & Other Natural Sleep Aids

      What they are: Natural sleep aids include dietary supplements, herbs, and other non-medication substances. Common natural sleep aids include:

      • Melatonin. A hormone naturally produced by the body to induce sleep, which can be taken as a dietary supplement as well
      • Valerian, chamomile, lemon balm, and passionflower. Herbs believed to have sleep-inducing and relaxation properties
      • Kava kava. An herb with relaxation properties, which is no longer recommended by many health care providers due to potential problems with liver toxicity
      • Theanine. A substance found in green tea that can promote relaxation and sleep.
      • Magnesium. A mineral that the body uses to relax muscles
      • Lavender. An aromatherapy herb (smelled, not taken orally) that may promote relaxation and restfulness
      • Hops. A plant best known as a flavoring component for beer, which can be used as a dietary supplement to manage insomnia
      • L-tryptophan. An amino acid (a building block for protein) that may improve sleep for some people

      Why to buy: Some of these herbs and dietary supplements have research to support that they may be helpful for managing insomnia, including melatonin, valerian, chamomile, passionflower, theanine, magnesium, hops, and L-tryptophan. They may be less likely to cause next-day grogginess than over-the-counter sleep medications.

      Things to consider: Natural does not always mean safe. All dietary supplements and herbs should be carefully reviewed with your healthcare provider or pharmacist. If you are managing a health condition, this will help to ensure a supplement is safe to combine with medications you are using. Use plant- and herb-based natural sleep aids with caution if you have hay fever or seasonal allergies; some of these products may cause allergic reactions in susceptible individuals. Natural sleep aids may not be safe for people with a history of mental health conditions, such as anxiety or depression. If in doubt, talk to your doctor first. Magnesium can have laxative effects, so start with a low dose to assess your tolerance to this mineral.

    • Stop-Snoring Products

      What they are: Stop-snoring products are designed to decrease bothersome snoring, either through physically opening breathing passageways, or by changing how the muscles in the mouth and throat are contracting or relaxing. Mouthpieces and nasal clips and strips are used to open breathing passages. Homeopathic, herbal, and other natural substances are taken orally or sprayed into the throat to ease snoring.

      Why to buy: Some people find stop-snoring products to be helpful. They are relatively inexpensive and the products designed to physically open breathing passages are safe for nearly everyone.

      Things to consider: Snoring can signal a serious health condition, such as sleep apnea. If you’ve developed snoring recently, if your snoring is severe, or if you are groggy most of the time during the day, talk to your doctor before you try to self-treat snoring.

  • Pain Relievers

    Your body uses pain to tell you something is wrong, but in many cases, the problem is minor and may be managed at home with the help of an over-the-counter pain reliever. However, not every pain reliever is right for every situation, and, like all medicines, they should be used with care. Use this quick guide to pick the one that can maximize the benefits and minimize the risks of using these products. As you choose an over-the-counter pain reliever, keep the following in mind:

    • Talk to your doctor if you experience prolonged or severe pain; unchecked pain can signal something serious that requires medical care.
    • Always compare ingredients to avoid accidentally taking two medications together that contain the same active ingredients.
    • If you are treating several aches and pains at once, check with your doctor or pharmacist about which medications are okay to use together.
    • Ask your doctor or pharmacist how best to avoid mixing drugs that should not be combined, including combinations of over-the-counter and prescription medications.
    • Nonsteroidal Anti-inflammatory Drugs

      What they are: Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin and the non-aspirin medications ibuprofen and naproxen. NSAIDs block the production of prostaglandins, substances made by the body that cause pain, inflammation, and fever.

      Why to buy: NSAIDs relieve muscular and joint pain and may help manage menstrual cramps. Some people find them helpful for treating headaches, especially aspirin (see specialty pain relievers below for more information). NSAIDs may also lessen pain associated with colds, flu, and toothaches.

      Things to consider: Non-aspirin NSAIDs (ibuprofen, naproxen) slightly increase the risk of heart attack, while aspirin decreases heart attack risk. If you have existing heart disease, or if you already take daily aspirin to lower heart attack risk, consult your doctor before using ibuprofen, naproxen, or additional aspirin. All NSAIDs may increase the risk of bleeding and may cause ulcers in some people. If you have a sensitive stomach, acetaminophen may be a better option.

      Children and teens should not use aspirin or ibuprofen as it can lead to a rare, life-threatening reaction called Reye’s (pronounced “rise”) syndrome in these age groups.

    • Acetaminophen

      What it is: Acetaminophen is a non-NSAID pain reliever and fever reducer that is believed to work by decreasing the body’s sensitivity to pain (in other words, by raising the pain threshold).

      Why to buy: Acetaminophen is a fever reducer that may help manage many of the same pains as NSAIDs, including headaches, toothaches, muscular and joint pain, menstrual cramps, and painful cold and flu symptoms. Acetaminophen often is used instead of NSAIDs, because it is easier on the stomach, and is safe for use in children and teens.

      Things to consider: Use as directed. Exceeding the recommended dosage can cause liver disease and even death. Use caution with acetaminophen and alcohol as this combination can harm the liver. Acetaminophen may not be right for people with liver disease or abnormal liver function.If in doubt, always consult your doctor.

    • Specialty Pain Relievers

      What they are: Specialty pain relievers include those that contain NSAIDs or acetaminophen, plus other ingredients to treat a particular issue.

      Why to buy: People use specialty pain relievers when they have a cold or flu, to help them sleep when they have pain, or to treat severe headaches such as migraines. The additional ingredients are targeted to the problem. For example, cold and flu products may contain pseudoephedrine, dextromethorphan, or guaifenesin, to manage sinus pain, cough, and congestion, respectively. Migraine formulas often contain aspirin, caffeine, and acetaminophen, a combination especially effective for headaches.

      Things to consider: These products contain the same ingredients as regular pain relievers—either NSAIDs or acetaminophen—so apply the same cautions. Additionally, you may need to avoid other ingredients in these products. Consult your doctor if you are unsure.

      Some specialty pain relievers are not safe for use in young children and those that contain aspirin always should be avoided. Ask your pediatrician or pharmacist if you need help selecting an appropriate product for your child.

    • Topical Pain Relievers

      What they are: “Topical” refers to pain relievers that are applied to the skin. They may contain NSAIDs like aspirin or diclofenac, or anaesthetic aromatic compounds like menthol and camphor. These aromatic compounds can be derived from plants but most commercial products contain synthetic versions. Menthol is derived from plants in the mint family and creates a cool sensation; camphor is derived primarily from the camphor laurel tree and may produce either warm or cool sensations. Some topical pain relievers combine menthol with methyl salicylate, an aromatic compound from wintergreen that is chemically similar to aspirin.

      Why to buy: If you have pain over a small area, such as a muscle or joint, a topical pain reliever can deliver medicine straight to the area, without having to go through the digestive tract. This may bring faster relief, typically with fewer side effects.

      Things to consider: If a topical pain reliever contains the same active ingredient as another medication you are using, such as aspirin, do not take the two products together. Pain relievers applied to the skin are still drugs and should be treated as such.The same cautions apply, such as avoiding topical aspirin if you already take daily aspirin or if you are at risk of bleeding or ulcers. Do not use aspirin-based topical pain relievers on children or teens without first checking with your doctor. If you choose a topical preparation with aromatic compounds, check to see if methyl salicylate or wintergreen oil is on the list of ingredients. Methyl salicylate overdose can occur if it is used over a large area of the body or very often. The risk of overdose is higher for babies and toddlers.

  • Immune-System Support

    Your immune system is constantly working to keep you healthy and strong. Sometimes it needs a little help—especially during back-to-school and winter seasons when germs run wild. Give your immune system some support with these simple but effective tips and products. And always drink plenty of fluids—staying hydrated is a key ingredient to staying healthy.
    • Immunity-Supporting Products

      What they are: The best offense is a good defense. Immunity-supporting products are formulated and packaged to support immune function at times when your system is under threat. Most commonly, these products contain vitamin C or zinc, and come in a variety of forms that make it easy to take at the earliest sign of cold symptoms, or other common infections that strike when you’re feeling run down.

      Why use them: Studies have shown the positive health and immune benefits of taking vitamin C and zinc, especially at the first signs of sickness, and these types of nutritional products are safe and easy to take. They’re available in a variety of formulas such as chewables, quick-dissolving tablets, nasal sprays (except zinc nasal sprays, which have been associated with loss of smell), lozenges, and effervescent drink powders you add to cold or hot water.

      Things to consider: Before adding supplements to your diet, make sure you consult your doctor and do your homework.

    • Immunity Products for Children

      What they are: Similar to adult products, but formulated in lower, kid-friendly dosages to best support their kid-size immune systems.

      Why use them: A safe and easy way to boost their defenses, children’s immune products are usually available as gummies or chewables in a variety of fun flavors, making it easier to get your little ones to take their vitamins.

      Things to consider: Look for supplements formulated for your child’s age range. If your child has never taken supplements before, it is best to talk with their pediatrician first, especially if they’re taking medications.

    • Probiotics: Digestive Support

      What they are: To keep your immune system strong, probiotics like acidophilus support healthy digestion and naturally boost your body’s defenses.

      Why use them: Research suggests probiotics may help prevent colds and can help to balance the good bacteria in your digestive system to keep it on track.

      Things to consider: Not all probiotic formulas have the same effects on the body, and some products contain more “friendly bacteria" than others. Refrigerated probiotic products, including those that are added to yogurts and other foods, are often a good bet, as the colony-forming units are likely to be preserved. However, probiotic powders are also available in capsules and packets.

    • Enhanced Waters & Drinks

      What they are:These beverages often include a mix of vitamins and minerals for overall vitality, such as B-complex and vitamin C.

      Why use them: Vitamin-enhanced waters and drinks have not been well studied, but as long as they are not laden with sugar, they may provide some extra vitamins—and at the very least they can help you stay hydrated.

      Things to consider: Pay attention and read labels so you don’t get more than you bargained for, as many may also include sugar and stimulants such as caffeine, guarana, and ginseng. And make note of how many servings are in the container, as calories from enhanced beverages can add up fast—or try one of the low- or no-calorie varieties.

  • Hot & Cold Therapies

    Hot and cold therapies, such as heating pads and ice packs, use varying temperatures to treat injury or illness. Many people use hot or cold therapy to lessen symptoms and decrease pain and swelling associated with a variety of conditions, such as arthritis, aches and strains, muscle spasms and pulls, tennis elbow, runner’s knee, and minor bumps and bruises. As you choose a hot or cold therapy product to manage minor injuries or aches at home, keep the following in mind:

    • Talk to your doctor if you experience prolonged or severe pain; unchecked pain can signal a serious condition that may require medical care.
    • Cold therapy generally is recommended for the first two to three days after acute injuries, such as a twisted ankle or a new bruise.
    • Heat therapy can be helpful for some chronic conditions, such as joint pain due to arthritis or tight, knotted muscles.
    • Consider the shape and size of product that best suits your needs. Hot and cold therapies come as bands or wraps, with and without pressure points to target specific issues, and in kid-friendly sizes and shapes.
    • Consult your doctor or pharmacist if unsure about whether hot or cold therapy is best for your condition.
    • Dual Hot & Cold Therapies

      What they are: These products contain gels or other materials that can be used hot or cold. When placed in the freezer before use, they become cold therapy. To use as hot therapy, the product can be heated in hot water or the microwave.

      Why to buy: If you aren’t sure whether you need hot or cold therapy, a dual use product will give you both options.

      Things to consider: Determine how long it takes the product to become hot or cold enough for use, how long you can expect the pack to stay hot or cold when in use, and whether this fits your needs. Some products can be microwaved for quick heat up, while others have to be placed in hot or boiling water, which takes a little more time and effort.

    • Hot Therapies

      What they are: These products are designed to supply heat only. They include electric hot pads, heatable gel pads, hot water bottles, and single use “sticky” products that are applied directly to the skin.

      Why to buy: If you have a chronic condition that responds well to heat, focus on getting the best heat source for your money.

      Things to consider: Electric heating pads stay hot as long as they are plugged in, but you must stay near an outlet. It is not safe to sleep on or with most electric hot pads, so choose another option for nighttime use. Heatable gel pads and sticky pads are more portable, but the heat lasts only for an hour to a few hours.

    • Cold Therapies

      What they are: These products are designed to supply cold only. They include ice packs and freezable gel packs.

      Why to buy: If you know you need cold to treat your condition, keeping one or two of these products in the freezer provides cold therapy right when you want it. If you want cold longer than a single product provides, rotate two packs into and out of the freezer.

      Things to consider: Do not use cold therapy for longer than recommended, because long periods of cold exposure can damage skin. Place a towel between the ice pack and your skin if recommended in product instructions.

    • Topical Hot & Cold Products

      What they are: Topical products provide a hot or cold sensation over the area to which they are applied. Some products start with a cold sensation and move toward heat over time.

      Why to buy: These products are quick and convenient—you rub onto the skin and go. Many are formulated so they don’t stain clothing or have a strong odor. Some products have a pleasant odor, adding aromatherapy to the healing experience.

      Things to consider: Some hot and cold therapies are topical, meaning they are applied to the skin. These may contain additional pain-relieving medicines, such as aspirin (products with aspirin should not be given to children). Always compare ingredients to avoid accidentally combining more than one therapy with the same active ingredients. If unsure, check with your doctor or pharmacist about whether these are safe for you. Test any topical product on a small area prior to full application, to ensure it doesn’t cause skin irritation or an allergic reaction.

References

1. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45.

2. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-98.

3. Li XY. Immunomodulating Chinese herbal medicines. Mem Inst Oswaldo Cruz 1991;86 Suppl 2:159-64.

4. Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 2000;72:345-93.

5. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-21.

6. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-7.

7. Chavance M, Herbeth B, Lemoine A, et al. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.Int.J Vitam Nutr Res 1993;63:11-6.

8. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.

9. Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71.

10. Wagner H, Nörr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1:63-76.

11. Bone K. Clinical Applications of Ayurvedic and Chinese Herbs. Queensland, Australia: Phytotherapy Press, 1996, 137-41.

12. Scaglione F, Ferrara F, Dugnani S, et al. Immunomodulatory effects of two extracts of Panax ginseng CA Meyer. Drugs Exp Clin Res 1990;16:537-42.

13. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-21.

14. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-7.

15. Chavance M, Herbeth B, Lemoine A, et al. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.Int.J Vitam Nutr Res 1993;63:11-6.

16. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.

17. Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71.

18. Chew BP. Role of carotenoids in the immune response. J Dairy Sci 1993;76:2804-11.

19. Bendich A. Beta-carotene and the immune response. Proc Nutr Soc 1991;50:263-74.

20. Hughes DA, Wright AJ, Finglas PM, et al. The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers. J Lab Clin Med 1997;129:309-17.

21. Murata T, Tamai H, Morinobu T, et al. Effect of long-term administration of beta-carotene on lymphocyte subsets in humans. Am J Clin Nutr 1994;60:597-602.

22. Santos MS, Meydani SN, Leka L, et al. Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. Am J Clin Nutr 1996;64:772-7.

23. Santos MS, Leka LS, Ribaya-Mercado JD, et al. Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons. Am J Clin Nutr 1997;66:917-24.

24. Kazi N, Radvany R, Oldham T, et al. Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer. Nutr Cancer 1997;28:140-5.

25. Fuller CJ, Faulkner H, Bendich A, et al. Effect of beta-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men. Am J Clin Nutr 1992;56:684-90.

26. Coodley GO, Coodley MK, Lusk R, et al. Beta-carotene in HIV infection: an extended evaluation. AIDS 1996;10:967-73.

27. Fryburg DA, Mark RJ, Griffith BP, et al. The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study. Yale J Biol Med 1995;68:19-23.

28. See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 1997;35:229-35.

29. Melchart D, Linde K, Worku F, et al. Immunomodulation with echinacea—a systematic review of controlled clinical trials. Phytomedicine 1994;1:245-54 [review].

30. Melchart D, Linde K, Worku F, et al. Results of five randomized studies on the immunomodulatory activity of preparations of echinacea. J Alt Compl Med 1995;1:145-60.

31. Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: Recent trends in the Soviet literature. J Ethnopharmacol 1982;6:339-53 [review].

32. Fernandes CF, Shahani KM, Amer MA. Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products. FEMS Micro Rev 1987;46:343-56.

33. Bengmark S. Immunonutrition: role of biosurfactants, fiber, and probiotic bacteria. Nutrition 1998;14:585-94 [review].

34. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.

35. Pedone CA, Arnaud CC, Postaire ER, et al. Multicentric study of the effect of milk fermented by Lactobacilus casei on the incidence of diarrhea. Int J Clin Pract 2000;54:568-71.

36. Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000;95:S16-8 [review].

37. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-21.

38. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-7.

39. Chavance M, Herbeth B, Lemoine A, et al. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.Int.J Vitam Nutr Res 1993;63:11-6.

40. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.

41. Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71.

42. Fiocchi A, Borella E, Riva E, et al. Double-blind clinical trial for the evaluation of the therapeutical effectiveness of a calf thymus derivative (Thymomodulin) in children with recurrent respiratory infections. Thymus 1986;8:331-9.

43. Galli L, de Martino M, Azzari C, et al. Preventive effect of thymomodulin in recurrent respiratory infections in children. Pediatr Med Chir 1990;12:229-32.

44. Vettori G, Lazzaro A, Mazzanti P, Cazzola P. Prevention of recurrent respiratory infections in adults. Minerva Med 1987;78:1281-9.

45. Longo F, Lepore L, Agosti E, Panizon F. Evaluation of the effectiveness of thymomodulin in children with recurrent respiratory infections. Pediatr Med Chir 1988;10:603-7.

46. Maiorano V, Chianese R, Fumarulo R, et al. Thymomodulin increases the depressed production of superoxide anion by alveolar macrophages in patients with chronic bronchitis. Int J Tissue React 1989;11:21-5.

47. Garagiola U, Buzzetti M, Cardella E. Immunological patterns during regular intensive training in athletes: quantification and evaluation of a preventive pharmacological approach. J Int Med Res 1995;23:85-95.

48. Wysocki J, Wierusz-Wysocka B, Wykretowicz A, Wysocki H. The influence of thymus extracts on the chemotaxis of polymorphonuclear neutrophils (PMN) from patients with insulin-dependent diabetes mellitus (IDD). Thymus 1992;20:63-7.

49. Calsini P, Mocchegiani E, Fabris N. The pharmacodynamics of thymomodulin in elderly humans. Drugs Exp Clin Res 1985;11:671-4.

50. Braga PC, Dal Sasso M, Maci S, et al. Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. J Chemother 1994;6:354-9.

51. Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis 1994;19:489-99 [review].

52. Glasziou PP, Mackerras DE. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ 1993;306:366-70.

53. Stephensen CB, Franchi LM, Hernandez H, et al. Adverse effects of high-dose vitamin A supplements in children hospitalized with pneumonia. Pediatrics 1998;101(5):E3 [abstract].

54. Bresee JS, Fischer M, Dowell SF, et al. Vitamin A therapy for children with respiratory syncytial virus infection: a multicenter trial in the United States. Pediatr Infect Dis J 1996;15:777-82.

55. Quinlan KP, Hayani KC. Vitamin A and respiratory syncytial virus infection. Serum levels and supplementation trial. Arch Pediatr Adolesc Med 1996;150:25-30.

56. Kjolhede CL, Chew FJ, Gadomski AM, et al. Clinical trial of vitamin A as adjuvant treatment for lower respiratory tract infections. J Pediatr 1995;126:807-12.

57. Pinnock CB, Douglas RM, Badcock NR. Vitamin A status in children who are prone to respiratory tract infections. Aust Paediatr J 1986;22:95-9.

58. Murphy S, West KP Jr, Greenough WB 3d, et al. Impact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial. Age Ageing 1992;21:435-9.

59. Fawzi WW, Mbise R, Spiegelman D, et al. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. J Pediatr 2000;137:660-7.

60. Ross AC. Vitamin A supplementation as therapy—are the benefits disease specific? Am J Clin Nutr 1998;68:8-9 [review].

61. Fawzi WW, Mbise RL, Fataki MR, et al. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. Am J Clin Nutr 1998;68:187-92.

62. Committee on Infectious Diseases, American Academy of Pediatrics. Vitamin A treatment of Measles. Pediatrics 1993;91:1014-5.

63. Penn ND, Purkins L, Kelleher J, et al. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing 1991;20:169-74.

64. de la Fuente M, Ferrandez MD, Burgos MS, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998;76:373-80.

65. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-21.

66. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-7.

67. Chavance M, Herbeth B, Lemoine A, et al. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.Int.J Vitam Nutr Res 1993;63:11-6.

68. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.

69. Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71.

70. Geber WF, Lefkowitz SS, Hung CY. Effect of ascorbic acid, sodium salicylate, and caffeine on the serum interferon level in response to viral infection. Pharmacology 1975;13:228-33.

71. Anderson R. The immunostimulatory, anti-inflammatory an anti-allergic properties of ascorbate. Adv Nutr Res 1984;6:19-45 [review].

72. Banic S. Immunostimulation by vitamin C. Int J Vitam Nutr Res Suppl 1982;23:49-52 [review].

73. Delafuente JC, Prendergast JM, Modigh A. Immunologic modulation by vitamin C in the elderly. Int J Immunopharmacol 1986;8:205-11.

74. Kennes B, Dumont I, Brohee D, et al. Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology 1983;29:305-10.

75. Murata A. Virucidal activity of vitamin C for prevention and treatment of viral diseases. In Proceedings of the First Intersectional Congress of IAMS, vol 3. Science Council Japan, 1975, 432.

76. Knodell RG, Tate MA, Akl BF, Wilson JW. Vitamin C prophylaxis for post transfusion hepatitis: lack of effect in a controlled trial. Am J Clin Nutr 1981;34:20-3.

77. Hemila H. Vitamin C and the common cold. Br J Nutr 1992;67:3-16.

78. HemilÀ H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med 1996;17:379-83.

79. Penn ND, Purkins L, Kelleher J, et al. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing 1991;20:169-74.

80. de la Fuente M, Ferrandez MD, Burgos MS, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998;76:373-80.

81. Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs. Warwick, Queensland, Australia: Phytotherapy Press, 1996, 13-20.

82. Nanba H. Antitumor activity of orally administered ‘D-fraction' from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;4:10-5.

83. Pengelly A. Medicinal fungi of the world. Modern Phytotherapist 1996;2:1, 3-8 [review].

84. Czop JK. The role of beta-glucan receptors on blood and tissue leukocytes in phagocytosis and metabolic activation. Pathol Immunopathol Res 1986;5:286-96.

85. Wakshull E, Brunke-Reese D, Lindermuth J, et al. PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor. Immunopharmacology 1999;41:89-107.

86. Czop JK, Kay J. Isolation and characterization of beta-glucan receptors on human mononuclear phagocytes. J Exp Med 1991;173:1511-20.

87. Czop JK, Puglisi AV, Miorandi DZ, Austen KF. Perturbation of beta-glucan receptors on human neutrophils initiates phagocytosis and leukotriene B4 production. J Immunol 1988;141:3170-6.

88. Estrada A, Yun CH, Van Kessel A, et al. Immunomodulatory activities of oat beta-glucan in vitro and in vivo. Microbiol Immunol 1997;41:991-8.

89. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem 2000;7:715-29 [review].

90. Ross GD, Vetvicka V, Yan J, et al. Therapeutic intervention with complement and beta-glucan in cancer. Immunopharmacology 1999;42:61-74.

91. Di Renzo L, Yefenof E, Klein E. The function of human NK cells is enhanced by beta-glucan, a ligand of CR3 (CD11b/CD18). Eur J Immunol 1991;21:1755-8.

92. Keplinger H. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same. US Patent no. 5,302,611, April 12, 1994.

93. Zhu JL, Liu C. Modulating effects of extractum semen persicae and cultivated cordyceps hyphae on immuno-dysfunction of inpatients with posthepatitic cirrhosis. Zhongguo Zhong Xi Yi Jie He Za Zhi 1992;12(4):207-9, 195 [in Chinese.

94. Nakamura K, Yamaguchi Y, Kagota S, et al. Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats. Jpn J Pharmacol 1999;79:505-8.

95. Khorram O, Vu L, Yen SS. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A Biol Sci Med Sci 1997;52:M1-7.

96. Casson PR, Andersen RN, Herrod HG, et al. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol 1993;169:1536-9.

97. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Bioch 1995;22:169-80.

98. You SQ. Study on feasibility of Chinese green tea polyphenols (CTP) for preventing dental caries. Chin J Stom 1993;28(4):197-9.

99. Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995;39:2375-7.

100. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 350-2.

101. Corridan BM, O'Donohue MP, Morrissey PA. Carotenoids and immune response in elderly people. Proc Nutr Soc 1998;57:3A-4A.

102. Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs. Warwick, Queensland, Australia: Phytotherapy Press, 1996, 13-20.

103. Nanba H. Antitumor activity of orally administered ‘D-fraction' from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;4:10-5.

104. Pengelly A. Medicinal fungi of the world. Modern Phytotherapist 1996;2:1, 3-8 [review].

105. Hirazumi A, Furusawa E, Chou SC, Hokama Y. Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 1996;39:7-9 .

106. Tamura J, Kubota K, Murakami H, et al. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 1999;116:28-32.

107. Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr 2002;41:12-8.

108. Wong KF, Middleton N, Montgomery M, et al. Immunostimulation of murine spleen cells by materials associated with bovine milk protein fractions. J Dairy Sci 1998;81:1825-32.

109. Cross ML, Gill HS. Modulation of immune function by a modified bovine whey protein concentrate. Immunol Cell Biol 1999;77:345-50.

110. Minehira K, Inoue S, Nonaka M, et al. Effects of dietary protein type on oxidized cholesterol-induced alteration in age-related modulation of lipid metabolism and indices of immune function in rats. Biochim Biophys Acta 2000;1483:141-53.

111. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-21.

112. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992;340:1124-7.

113. Chavance M, Herbeth B, Lemoine A, et al. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.Int.J Vitam Nutr Res 1993;63:11-6.

114. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107.

115. Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71.

116. Duchateau J, Delespesse G, Vereecke P. Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects. Am J Clin Nutr 1981;34:88-93.

117. Fraker PJ, Gershwin ME, Good RA, Prasad A. Interrelationships between zinc and immune function. Fed Proc 1986;45:1474-9.

118. Fortes C, Forastiere F, Agabiti N, et al. The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 1998;46:19-26.

119. Chandra RK. Excessive intake of zinc impairs immune responses. JAMA 1984;252:1443.

120. Macknin ML. Zinc lozenges for the common cold. Cleve Clin J Med 1999;66:27-32 [review].

121. Herbert TB, Cohen S. Stress and immunity in humans: a meta-analytic review. Psychosom Med 1993;55:364-79 [review].

122. Palmblad JE. Stress-related modulation of immunity: a review of human studies. Cancer Detect Prev Suppl 1987;1:57-64 [review].

123. Kemeny ME, Gruenewald TL. Psychoneuroimmunology update. Semin Gastrointest Dis 1999;10:20-9 [review].

124. Halley FM. Self-regulation of the immune system through biobehavioral strategies. Biofeedback Self Regul 1991;16:55-74 [review].

125. Whitehouse WG, Dinges DF, Orne EC, et al. Psychosocial and immune effects of self-hypnosis training for stress management throughout the first semester of medical school. Psychosom Med 1996;58:249-63.

126. Kelley DS, Daudu PA. Fat intake and immune response. Prog Food Nutr Sci 1993;17:41-63 [review].

127. Yaqoob P. Monounsaturated fats and immune function. Proc Nutr Soc 1998;57:511-20 [review].

128. Tashiro T, Yamamori H, Takagi K, et al. n-3 versus n-6 polyunsaturated fatty acids in critical illness. Nutrition 1998;14:551-3.

129. Gerster H. The use of n-3 PUFAs (fish oil) in enteral nutrition. Int J Vitam Nutr Res 1995;65:3-20 [review].

130. Meydani SN, Lichtenstein AH, Cornwall S, et al. Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 1993;92:105-13.

131. Kelley DS, Taylor PC, Nelson GJ, et al. Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. Lipids 1999;34:317-24.

132. Wu D, Meydani SN. n-3 polyunsaturated fatty acids and immune function. Proc Nutr Soc 1998;57:503-9 [review].

133. Kelley DS, Dougherty RM, Branch LB, et al. Concentration of dietary N-6 polyunsaturated fatty acids and the human immune status. Clin Immunol Immunopathol 1992;62:240-4.

134. Rasmussen LB, Kiens B, Pedersen BK, et al. Effect of diet and plasma fatty acid composition on immune status in elderly men. Am J Clin Nutr 1994;59:572-7.

135. Wan JM, Teo TC, Babayan VK, et al. Invited comment: lipids and the development of immune dysfunction and infection. JPEN J Parenter Enteral Nutr 1988;12:43S-52S.

136. Meydani SN, Ha WK. Immunologic effects of yogurt. Am J Clin Nutr 2000;71:861-72 [review].

137. Sanchez A, Reeser JL, Lau HS, et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr 1973;26:1180-4.

138. Ringsdorf WM, Cheraskin E, Ramsay RR. Sucrose, neutrophilic phagocytosis and resistance to disease. Dent Survey 1976;52(12):46.

139. Nutter RL, Gridley DS, Kettering JD, et al. Modification of a transplantable colon tumor and immune responses in mice fed different sources of protein, fat and carbohydrate. Cancer Lett 1983;18(1):49-62.

140. Kos WL, Kos KA, Kaplan AM. Impaired function of immune reactivity to Listeria monocytogenes in diet-fed mice. Infect Immun 1984;43:1094-6.

141. Ahmed FE. Toxicological effects of ethanol on human health. Crit Rev Toxicol 1995;25:347-67.

142. Szabo G. Monocytes, alcohol use, and altered immunity. Alcohol Clin Exp Res 1998;22:216-9S.

143. Seitz HK, Poschl G, Simanowski UA. Alcohol and cancer. Recent Dev Alcohol 1998;14:67-95 [review].

144. MacGregor RR, Louria DB. Alcohol and infection. Curr Clin Top Infect Dis 1997;17:291-315 [review].

145. Balla AK, Lischner HW, Pomerantz RJ, et al. Human studies on alcohol and susceptibility to HIV infection. Alcohol 1994;11:99-103 [review].

146. Engs RC, Aldo-Benson M. The association of alcohol consumption with self-reported illness in university students. Psychol Rep 1995;76:727-36.

147. Cohen S, Tyrrell DA, Russell MA, et al. Smoking, alcohol consumption, and susceptibility to the common cold. Am J Public Health 1993;83:1277-83.

148. Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr 1997;66:460-3S [review].

149. Stallone DD. The influence of obesity and its treatment on the immune system. Nutr Rev 1994;52:37-50.

150. Nieman DC, Nehlsen-Cannarella SI, Henson DA, et al. Immune response to obesity and moderate weight loss. Int J Obes Relat Metab Disord 1996;20:353-60.

151. Nieman DC, Henson DA, Nehlsen-Cannarella SL. Influence of obesity on immune function. J Am Diet Assoc 1999;99:294-9.

152. Scanga CB, Verde TJ, Paolone AM, et al. Effects of weight loss and exercise training on natural killer cell activity in obese women. Med Sci Sports Exerc 1998;30:1666-71.

153. Nieman DC. Exercise immunology: practical applications. Int J Sports Med 1997;18:S91-100 [review].

154. Nieman DC. Exercise and resistance to infection. Can J Physiol Pharmacol 1998;76:573-80 [review].

155. Shephard RJ, Shek PN. Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 1998;26:293-315 [review].

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.