Sodium Fluoride
Common brand names:
Fluor-A Day, Luride, PreviDent, ACT Fluoride, EtheDent, Gel-Kam, Karigel, PediaflorSodium fluoride is used to prevent dental cavities and might be effective in the treatment of osteoporosis.
Summary of Interactions with Vitamins, Herbs, & Foods
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Supportive Interactions
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Replenish Depleted Nutrients
Sodium Fluoride
Zinc
Individuals who are bedridden for long periods may become deficient in zinc, which can affect the strength of bone that is formed. In a controlled study of healthy adults who were confined to bed, fluoride supplementation prevented zinc loss from the body. Bedridden individuals should consult a qualified healthcare practitioner for guidance in using fluoride to prevent zinc deficiency.
ZincSodium Fluoride- Krebs JM, Schneider VS, LeBlanc AD. Zinc, copper and nitrogen balance during bed rest and fluoride supplementation in healthy adult males. Am J Clin Nutr 1998;47:509-14.
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Support Medicine
Sodium Fluoride
Vitamin D
Collagen is a protein that is used in many areas of the body for structural support. One test tube study showed that the active form of vitamin D, 1,25 dihydroxycholecalciferol, increased the production of a certain type of collagen when it was combined with fluoride. Controlled research is needed to determine whether taking 1,25 dihydroxycholecalciferol with sodium fluoride might promote beneficial collagen growth.
Vitamin DSodium Fluoride- Kassem M, Mosekilde L, Eriksen EF. 1,25-dihydroxy-vitamin D3 potentiates fluoride-stimulated collagen Type I production in cultures of human bone marrow stromal osteoblast-like cells. J Bone Miner Res 1993;8:1453-8.
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Support Medicine
Sodium Fluoride
Vitamin E
Vitamin E increases the resistance of tooth enamel to acids that cause cavities, and test tube studies show that fluoride, when added to vitamin E, enhances this effect. Controlled research is needed to determine whether people might develop fewer cavities when taking vitamin E and fluoride together.
Vitamin ESodium Fluoride- Yu H, Oho T, Xu LX. Effects of several tea components on acid resistance of human tooth enamel. J Dent 1995;23:101-5.
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Explanation Required
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Needs Explanation
Sodium Fluoride
Calcium
Research shows that calcium from leg bones may be transferred to bones in the spine causing stress fractures when fluoride is taken alone. However, supplementing with 1,500 mg of calcium each day together with slow-release forms of fluoride increases the bone density of the lumbar spine without causing fractures. Therefore, people taking sodium fluoride to treat osteoporosis should probably supplement with calcium to prevent this adverse effect. However, taking fluoride and calcium at the same time significantly reduces the absorption of fluoride; consequently, they should be taken at least an hour apart.
CalciumSodium Fluoride- Deal CL. Osteoporosis: prevention, diagnosis, and management. Am J Med 1997;102:35s-9s.
- Ekstrand J, Spak CJ. Fluoride pharmacokinetics: its implication in the fluoride treatment of osteoporosis. J Bone Miner Res 1990;5 Suppl 1:s53-61.
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