Nifedipine
Common brand names:
Adalat CC, Procardia, Procardia XL, Nifediac CC, Nifedical XLNifedipine is a calcium channel blocker used to treat angina pectoris and high blood pressure.
Summary of Interactions with Vitamins, Herbs, & Foods
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Explanation Required
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Needs Explanation
Nifedipine
Grapefruit
Ingestion of grapefruit juice has been shown to increase the absorption of felodipine (a drug similar in structure and action to that of nifedipine) and to increase the adverse effects of the medication in patients with hypertension. People taking nifedipine or similar drugs should not consume grapefruit juice or grapefruit, unless they have discussed it with their physician.
GrapefruitNifedipine- Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998;46:101-10.
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Needs Explanation
Nifedipine
Pleurisy Root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as calcium channel blockers.
Pleurisy RootNifedipine- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.
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Needs Explanation
Nifedipine
Pomegranate
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with nifedipine in the same way that grapefruit juice does.
PomegranateNifedipine- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
- Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
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