Drug

Metoclopramide

Common brand names:

Maxolon, Octamide PFS, Reglan

Metoclopramide is used to treat heartburn and regurgitation; to prevent vomiting in people receiving drugs to treat cancer; and to prevent nausea, vomiting, heartburn, and fullness after a meal in certain individuals with diabetes.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    2

    • Metoclopramide

      Foods with Lactose

      Potential Negative Interaction

      Individuals who have lactose intolerance (difficulty digesting milk sugar) may experience more severe symptoms while taking metoclopramide. Lactose is the milk sugar present in dairy products.

      Foods with Lactose
      Metoclopramide
      ×
      1. Peuhkuri K, Vapaatalo H, Nevala R, Korpela R. Influence of the pharmacological modification of gastric emptying on lactose digestion and gastrointestinal symptoms. Aliment Pharmacol Ther 1999;13:81-6.

    • Metoclopramide

      N-Acetyl Cysteine

      Potential Negative Interaction

      A single case report described a 15-year-old girl who suffered oxygen deprivation in her body tissues after being given high amounts of metoclopramide and N-acetyl-cysteine to treat her for an overdose of acetaminophen. It is unknown whether N-acetyl-cysteine supplementation in the absence of acetaminophen overdose could cause similar effects in people taking metoclopramide. Until controlled research determines the safety of this combination, it should be used only under the supervision of a qualified physician.

      N-Acetyl Cysteine
      Metoclopramide
      ×
      1. Langford JS, Sheikh S. An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteine. Ann Emerg Med 1999;34:538-41.

  • Supportive Interactions

    1

    • Metoclopramide

      White Willow

      Support Medicine

      Salicylic acid is a compound formed in the body from either aspirin or willow bark (Salix alba). Taking metoclopramide before aspirin or willow bark results in higher concentrations of salicylic acid and greater pain relief in people suffering from an acute migraine headache. Controlled studies are necessary to confirm the benefit of this interaction.

      White Willow
      Metoclopramide
      ×
      1. Miner JO. Drug interactions involving aspirin (acetylsalicylic acid) and salicylic acid. Clin Pharmacokinet 1989;17:327-44.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

Copyright © 2024 TraceGains, Inc. All rights reserved.

RxAnswers™ is a copyrighted product from TraceGains.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

There are some limitations on the information provided in “Nutrient Interactions.” Do NOT rely solely on the information in this article. Please read the disclaimer.

Learn more about TraceGains, the company.

Learn more about the authors of RxAnswers.

TraceGains and/or its suppliers make no warranties or representations as to the accuracy or completeness of this content herein or that of any organization referred or linked to within this content and will not be liable for any damages arising out of your access to or use of any information found herein or that of any organization referred to within this content.

Information expires December 2024.