Drug

Isotretinoin

Common brand names:

Accutane, Amnesteem, Claravis, Sotret

Isotretinoin is a modified vitamin A molecule used to treat severe acne vulgaris.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    1

    • Isotretinoin

      Vitamin A

      Potential Negative Interaction

      Although little is known about how isotretinoin interacts with real vitamin A, the two are structurally similar and have similar toxicities. Therefore, people taking isotretinoin should avoid vitamin A supplements at levels higher than typically found in a multivitamin (10,000 IU per day).

  • Supportive Interactions

    1

    • Isotretinoin

      Vitamin E

      Reduce Side Effects

      Preliminary research has found that combined administration of isotretinoin and vitamin E (alpha-tocopherol) substantially reduces the initial toxicity of high-dose isotretinoin without reducing drug efficacy. Additional research is needed to further clarify this potentially beneficial interaction.

      Vitamin E
      Isotretinoin
      ×
      1. Dimery IW, Hong WK, Lee JJ, et al. Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity. Ann Oncol 1997;8:85-9.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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