Fentanyl
Common brand names:
Duragesic, Actiq, Fentora, SublimazeFentanyl is used in surgery as a general anesthetic and is available in a patch form to treat severe, chronic pain. It is in a class of drugs known as opioid analgesics.
Summary of Interactions with Vitamins, Herbs, & Foods
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Negative Interactions
3-
Reduces Effectiveness
Fentanyl
Apples
Drinking grapefruit juice, orange juice, or apple juice with fexofenadine decreases blood levels of the drug.
ApplesFentanyl- Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002;71:11-20.
- Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin PharmacolTher2005;77:170-7.
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Reduces Effectiveness
Fentanyl
Grapefruit
Drinking grapefruit juice, orange juice, or apple juice with fexofenadine decreases blood levels of the drug.
GrapefruitFentanyl- Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002;71:11-20.
- Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin PharmacolTher2005;77:170-7.
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Reduces Effectiveness
Fentanyl
Oranges
Drinking grapefruit juice, orange juice, or apple juice with fexofenadine decreases blood levels of the drug.
OrangesFentanyl- Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002;71:11-20.
- Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin PharmacolTher2005;77:170-7.
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Supportive Interactions
2-
Support Medicine
Fentanyl
Magnesium
One double-blind study showed that giving magnesium intravenously before surgery dramatically reduced the amount of fentanyl needed to control pain during and after an operation. Further research is needed to determine whether people using fentanyl patches might benefit from supplementing with oral magnesium.
MagnesiumFentanyl- Koinig H, Wallner T, Marhofer P, et al. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesth Analg 1998;87:206-10.
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Reduce Side Effects
Fentanyl
Fiber
This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.
Propoxyphene may cause gastrointestinal (GI) upset. Propoxyphene-containing products may be taken with food to reduce or prevent GI upset. A common side effect of narcotic analgesics is constipation. Increasing dietary fiber (especially vegetables and whole-grain foods) and water intake can ease constipation.
FiberFentanyl- Threlkeld DS, ed. Central Nervous System Drugs, Narcotic Agonist Analgesics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1990, 242-3v.
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