Fenofibrate
Common brand names:
Antara, TricorFenofibrate is used to lower elevated cholesterol and triglyceride levels when diet, exercise, and weight loss programs are ineffective. It is in a family of medications known as cholesterol-lowering drugs.
Summary of Interactions with Vitamins, Herbs, & Foods
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Supportive Interactions
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Reduce Side Effects
Fenofibrate
Folic Acid
Increased blood levels of homocysteine are associated with increased risk of atherosclerosis and heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced. In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy. Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Folic AcidFenofibrate- Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219-20.
- Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367-71.
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Reduce Side Effects
Fenofibrate
Vitamin B12
Increased blood levels of homocysteine are associated with increased risk of atherosclerosis and heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced. In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy. Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Vitamin B12Fenofibrate- Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219-20.
- Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367-71.
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Reduce Side Effects
Fenofibrate
Vitamin B6
Increased blood levels of homocysteine are associated with increased risk of atherosclerosis and heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced. In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy. Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Vitamin B6Fenofibrate- Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219-20.
- Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367-71.
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Reduce Side Effects
Fenofibrate
Vitamin C and Vitamin E
Several studies have shown that fenofibrate enhances the toxic effect of ultraviolet (UV) radiation from the sun, which might result in side effects such as skin rashes. One controlled study showed that taking 2 grams of vitamin C and 1,000 IU of vitamin E prior to ultraviolet exposure dramatically blocked UV-fenofibrate damage to red blood cells. though further controlled studies are needed, people taking fenofibrate should probably supplement with vitamins C and E until more information is available.
Vitamin C and Vitamin EFenofibrate- Eberlein-Konig B, Placzek M, Przybilla B. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997;13:173-7.
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