Drug

Doxylamine

Common brand names:

Aldex AN, Unisom Nighttime Sleep-Aid

Doxylamine is an antihistamine used for short-term treatment of insomnia. Doxylamine is available alone in a nonprescription product for sleep and in combination with nonprescription drugs to treat symptoms of allergy, colds, and upper respiratory infections.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    1

    • Doxylamine

      Henbane

      Potential Negative Interaction

      Antihistamines, including doxylamine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane (Hyoscyamus niger) also has anticholinergic activity and side effects. Therefore, use with doxylamine could increase the risk of anticholinergic side effects; however, apparently no interactions have yet been reported with doxylamine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.

      Henbane
      Doxylamine
      ×
      1. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council, 1998, 146.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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