Drug

Chlorpheniramine-Pseudoephed

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    1

    • Chlorpheniramine

      Henbane

      Potential Negative Interaction

      Antihistamines, including chlorpheniramine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane (Hyoscyamus niger) also has anticholinergic activity and side effects. Therefore, use of henbane with chlorpheniramine could increase the risk of anticholinergic side effects, though apparently no interactions have yet been reported. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.

      Henbane
      Chlorpheniramine
      ×
      1. Blumenthal M, ed. The Complete German Commission E Monographs. Austin, TX: American Botanical Council, 1998, 146.

  • Explanation Required

    1

    • Chlorpheniramine-Pseudoephed

      Fo-Ti

      Needs Explanation

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Many drugs used in the treatment of high blood pressure cause relaxation or dilation of blood vessels. Laboratory studies show that emodin, a compound in Polygonum multiflorum, also relaxes blood vessels. However, animal studies reveal that phenylephrine blocks the action of emodin. Controlled studies are needed to determine whether Polygonum multiflorum helps people with high blood pressure and whether phenylephrine blocks its beneficial effects.

      Fo-Ti
      Chlorpheniramine-Pseudoephed
      ×
      1. Huang HC, Lee CR, Chao PD, et al. Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb. Eur J Pharmacol 1991;205:289-94.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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