Drug

Cardec DM

Common brand names:

Cardec DM, Histadec DM, Rondec-DM, Robitussin Cough & Allergy Liquid, Robitussin Pediatric Cough & Cold Nighttime Liquid

Cardec DM® is a combination drug containing carbinoxamine (an antihistamine similar to diphenhydramine) plus pseudoephedrine and dextromethorphan. It is used to treat symptoms associated with the common cold and hay fever.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    9
    • Pseudoephedrine

      Coleus

      Potential Negative Interaction

      A test tube study demonstrated that the bronchodilating effects of salbutamol, a drug with similar actions in the lung to ephedrine, were significantly increased by the addition of forskolin, the active component of the herb Coleus forskohlii. The results of this preliminary research suggest that the combination of forskolin and beta-agonists (like ephedrine) might provide an alternative to raising the doses of the beta-agonist drugs as they lose effectiveness. Until more is known, coleus should not be combined with ephedrine without the supervision of a doctor.

      Coleus
      Pseudoephedrine
      ×
      1. Yousif MH, Thulesius O. Forskolin reverses tachyphylaxis to the bronchodilator effects of salbutamol: an in-vitro study on isolated guinea-pig trachea. J Pharm Pharmacol 1999;51:181-6.
    • Pseudoephedrine

      Ephedra

      Potential Negative Interaction

      Ephedra is the plant from which ephedrine was originally isolated. Until 2004, ephedra—also called ma huang—was used in many herbal products, including supplements promoted for weight loss. To prevent potentially serious interactions, people taking ephedrine or pseudoephedrine should avoid using ephedra-containing drug products and should read product labels carefully for ma huang or ephedra content. Native North American ephedra, sometimes called Mormon tea, contains no ephedrine.

    • Cardec DM

      Ephedra

      Potential Negative Interaction

      Ephedra is the plant from which ephedrine was originally isolated. Until 2004, ephedra—also called ma huang—was used in many herbal products including supplements promoted for weight loss. To prevent potentially serious interactions, people taking Cardec DM should avoid using ephedra-containing drug products and should read product labels carefully for ma huang or ephedra content. Native North American ephedra, sometimes called Mormon tea, contains no ephedrine.

    • Pseudoephedrine

      Foods with Caffeine

      Potential Negative Interaction

      Caffeine, which is found in coffee, tea, chocolate, guaraná (Paullinia cupana), and some nonprescription and supplement products, can amplify the side effects of ephedrine and pseudoephedrine. People should avoid combination products containing ephedrine/pseudoephedrine/ephedra and caffeine.

    • Cardec DM

      Foods with Caffeine

      Potential Negative Interaction

      Caffeine, which is found in coffee, tea, chocolate, guaraná (Paullinia cupana), and some nonprescription and supplement products, can amplify the side effects of ephedrine and pseudoephedrine. People should avoid combination products containing ephedrine/pseudoephedrine/ephedra and caffeine.

    • Cardec DM

      Green Tea

      Reduces Effectiveness

      Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs containing high amounts of tannins may interfere with the absorption of ephedrine or pseudoephedrine taken by mouth. Herbs containing high levels of tannins include green tea, black tea, uva ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus), oak (Quercus spp.), and witch hazel (Hamamelis virginiana).

      Green Tea
      Cardec DM
      ×
      1. Brinker F. Interactions of pharmaceutical and botanical medicines. J Naturopathic Med 1997;7(2):14-20.
    • Cardec DM

      Oak

      Reduces Effectiveness

      Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs containing high amounts of tannins may interfere with the absorption of ephedrine or pseudoephedrine taken by mouth. Herbs containing high levels of tannins include green tea, black tea, uva ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus), oak (Quercus spp.), and witch hazel (Hamamelis virginiana).

      Oak
      Cardec DM
      ×
      1. Brinker F. Interactions of pharmaceutical and botanical medicines. J Naturopathic Med 1997;7(2):14-20.
    • Pseudoephedrine

      Teas and Herbs with Tannin

      Reduces Effectiveness

      Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs containing high amounts of tannins may interfere with the absorption of ephedrine or pseudoephedrine taken by mouth. Herbs containing high levels of tannins include green tea, black tea, uva ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus),oak (Quercus spp.), and witch hazel (Hamamelis virginiana).

      Teas and Herbs with Tannin
      Pseudoephedrine
      ×
      1. Brinker F. Interactions of pharmaceutical and botanical medicines. J Naturopathic Med 1997;7(2):14-20.
    • Cardec DM

      Teas and Herbs with Tannin

      Reduces Effectiveness

      Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs containing high amounts of tannins may interfere with the absorption of ephedrine or pseudoephedrine taken by mouth. Herbs containing high levels of tannins include green tea, black tea, uva ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus), oak (Quercus spp.), and witch hazel (Hamamelis virginiana).

      Teas and Herbs with Tannin
      Cardec DM
      ×
      1. Brinker F. Interactions of pharmaceutical and botanical medicines. J Naturopathic Med 1997;7(2):14-20.
  • Explanation Required

    3
    • Pseudoephedrine

      Acidifying Foods

      Needs Explanation

      Foods that acidify the urine may increase the elimination of ephedrine from the body, potentially reducing the action of the drug. Urine-acidifying foods include eggs, peanuts, meat, chicken, wheat-containing foods, and others.

      Foods that alkalinize the urine may slow the elimination of ephedrine from the body, potentially increasing the actions and side effects of the drug. Urine-alkalinizing foods include dairy products, nuts, vegetables (except corn and lentils), most fruits, and others.

      Acidifying Foods
      Pseudoephedrine
      ×
      1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 105.
      2. Holt GA. Food & Drug Interactions. Chicago: Precept Press,1998, 105-6.
    • Cardec DM

      Acidifying Foods

      Needs Explanation

      Foods that acidify the urine may increase the elimination of ephedrine from the body, potentially reducing the action of the drug. Urine-acidifying foods include eggs, peanuts, meat, chicken, vitamin C (greater than 5 grams per day), wheat-containing foods, and others.

      Acidifying Foods
      Cardec DM
      ×
      1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 105.
    • Cardec DM

      Alkalinizing Foods

      Needs Explanation

      Foods that alkalinize the urine may slow the elimination of ephedrine from the body, potentially increasing the actions and side effects of the drug. Urine-alkalinizing foods include dairy products, nuts, vegetables (except corn and lentils), most fruits, and others.

      Alkalinizing Foods
      Cardec DM
      ×
      1. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 105-6.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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