Nutritional Supplement

Oregano/Wild Marjoram

Parts Used & Where Grown

Oregano is an aromatic perennial herb that can grow to about two feet in height. It is native to the Mediterranean region but is cultivated worldwide. In addition to European oregano, there are several types of related species, including Greek/Turkish oregano (Origanum onites) and Mexican oregano (Lippia graveolens, Lippa palmeri). These should not be considered substitutes for true oregano, though they may have similar properties. The leaves as well as the volatile oil of these various species are used medicinally, but must be carefully distinguished as they are quite different.1

How It Works

This dried herb contains several constituents, including volatile oil (up to 3%), such as carvacrol, thymol, and borneol, plus flavonoids, rosmarinic acid, triterpenoids (e.g. ursolic and oleanolic acid), sterols, and vitamin A and vitamin C.2 The thymol and carvacrol contents in oregano are responsible for its antimicrobial and antifungal effects.3 A test tube study demonstrated that oil of oregano, and carvacrol in particular, inhibited the growth of Candida albicans far more effectively than a commonly employed antifungal agent called calcium magnesium caprylate.4 Clinical studies are still needed to confirm these actions in humans.

In addition to its anti-fungal action, and according to the results of another test tube study from Australia, oregano oil has a strong anti-microbial action against a wide number of bacteria, including Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, and Staphylococcus aureus.5 Other test tube studies have shown that oregano from the Mexican (Lippia) species was more effective than the prescription medication tinidazol in inhibiting the parasite giardia (Giardia duodenalis).6 In another test tube study, volatile oils of oregano, thyme, cinnamon, and cumin were individually able to stop the growth of another food-borne pathogen called Aspergillus parasiticus. Higher concentrations of these volatile oils were also able to stop the production of aflatoxin, a potent poison from the food moldAspergillus.7 Together these facts suggest the volatile oils in oregano used during food processing have an important role in preventing the spoilage of food and in reducing the risk of ingesting harmful bacteria, fungi, and parasites. Again, these actions have not yet been confirmed by human clinical trials.

The German Commission E does not approve oregano for any medical indication.8

References

1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients, 2nd ed. New York: John Wiley & Sons, 1996, 398-9.

2. Wren RC. Potter's New Cyclopedia of Botanical Drugs and Preparations. Essex, England: C.W. Daniel, 1985, 185.

3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients, 2nd ed. New York: John Wiley & Sons, 1996, 398-9.

4. Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96-102.

5. Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985-90.

6. Ponce MM, Navarro AI, Martinez GMN, et al. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343-7 [in Spanish].

7. Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67-72.

8. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 358-9.

9. Forster HB, Niklas H, Lutz S. Antispasmodic effects of some medicinal plants. Planta Med 1980;40:303-19.

10. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 425-6.

11. Weiss RF. Herbal Medicine. Beaconsfield, UK: Beaconsfield Publishers Ltd, 1988, 185-6.

12. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 198.

13. Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96-102.

14. Hammer KA, Carson CF, Riley TV. In-vitro activity of essential oils, in particular Melaleuca alternafolia (tea tree) oil and tea tree oil products, against Candida albicans. J Antimicrobial Chemother 1998;42:591-5.

15. Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96-102.

16. Hammer KA, Carson CF, Riley TV. In-vitro activity of essential oils, in particular Melaleuca alternafolia (tea tree) oil and tea tree oil products, against Candida albicans. J Antimicrobial Chemother 1998;42:591-5.

17. Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96-102.

18. Grieve M. A Modern Herbal, vol II. New York: Dover Publications, 1982, 520-1.

19. Castleman M. The Healing Herbs. Emmaus, PA: Rodale Press, 1991, 275-6.

20. Peirce A. Practical Guide to Natural Medicines. New York: William Morrow and Co., 1999, 476-7.

21. Blumenthal M, Busse WR, Goldberg A, et al, eds.The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston: Integrative Medicine Communications, 1998, 358-9.

22. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 80.

23. Tisserand R, Balacs T.Essential Oil Safety. New York: Churchill Livingston, 1996, 234-5.

24. Tisserand R, Balacs T. Essential Oil Safety. New York: Churchill Livingston, 1996, 156-7.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.