Nutritional Supplement

Goji Berry

Also indexed as: Lycium barbarum, Lycium chinense

  • Negative Interactions

    1

    • Goji Berry

      Warfarin

      Potential Negative Interaction

      There is one reported case of increased bleeding tendency in a woman taking warfarin who also drank 3 to 4 glasses per day of goji berry tea.

References

1. Duke, JA. Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants. Boca Raton, FL: CRC Press, 1992.

2. Li XM, Ma YL, Liu XJ. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol 2007;111:504-11.

3. Li XM. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int J Biol Macromol 2007;40:461-5.

4. Wu H, Guo H, Zhao R. Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi 2006;126:365-71.

5. Zhao R, Li Q, Xiao B. Effect of Lycium barbarum polysaccharide on the improvement of insulin resistance in NIDDM rats. Yakugaku Zasshi 2005;125:981-8.

6. Luo Q, Cai Y, Yan J, et al. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci 2004;76:137-49.

7. Huang X, Yang M, Wu X, Yan J. Study on protective action of Lycium barbarum polysaccharides on DNA imparments of testicle cells in mice. Wei Sheng Yan Jiu 2003;32:599-601 [in Chinese].

8. Gan L, Wang J, Zhang S. Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide. Wei Sheng Yan Jiu 2001;30:333-5 [in Chinese].

9. Zhang M, Chen H, Huang J, et al. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci 2005;76:2115-24.

10. Luo Q, Yan J, Zhang S. Effects of pure and crude Lycium barbarum polysaccharides on immunopharmacology. Zhong Yao Cai 1999;22:246-9 [in Chinese].

11. Gan L, Hua Zhang S, Liang Yang X, Bi Xu H. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int Immunopharmacol 2004;4:563-9.

12. He YL, Ying Y, Xu YL, et al. Effects of Lycium barbarum polysaccharide on tumor microenvironment T-lymphocyte subsets and dendritic cells in H22-bearing mice. Zhong Xi Yi Jie He Xue Bao 2005;3:374-7 [in Chinese].

13. Luo Q, Yan J, Zhang S. Isolation and purification of Lycium barbarum polysaccharides and its antifatigue effect. Wei Sheng Yan Jiu 2000;29:115-7 [in Chinese].

14. Luo Q, Li Z, Huang X, Yan J, et al. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sci 2006;79:613-21.

15. Peng Y, Ma C, Li Y, et al. Quantification of zeaxanthin dipalmitate and total carotenoids in lycium fruits (Fructus Lycii). Plant Foods Hum Nutr 2005;60:161-4.

16. Zhou L, Leung I, Tso MO, Lam KW. The identification of dipalmityl zeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry. J Ocul Pharmacol Ther 1999;15:557-65.

17. Khachik F, Beecher GR, Smith JC Jr. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem Suppl 1995;22:236-46.

18. Cheng CY, Chung WY, Szeto YT, Benzie IF. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial. Br J Nutr 2005;93:123-30.

19. Benzie IF, Chung WY, Wang J, et al. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr 2006;96:154-60.

20. Leung I, Tso M, Li W, Lam T. Absorption and tissue distribution of zeaxanthin and lutein in rhesus monkeys after taking Fructus lycii (Gou Qi Zi) extract. Invest Ophthalmol Vis Sci 2001;42:466-71.

21. Kim HP, Lee EJ, Kim YC, et al. Zeaxanthin dipalmitate from lycium Chinense fruit reduces experimentally induced hepatic fibrosis in rats. Biol Pharm Bull 2002;25:390-2.

22. Gu S, Wang PL, Jiang R. A study on the preventive effect of Lycium barbarum polysaccharide on the development of alcoholic fatty liver in rats and its possible mechanisms. Zhonghua Gan Zang Bing Za Zhi 2007;15:204-8 [in Chinese].

23. Peng Y, Ma C, Li Y, et al. Quantification of zeaxanthin dipalmitate and total carotenoids in lycium fruits (Fructus Lycii). Plant Foods Hum Nutr 2005;60:161-4.

24. Zhou L, Leung I, Tso MO, Lam KW. The identification of dipalmityl zeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry. J Ocul Pharmacol Ther 1999;15:557-65.

25. Khachik F, Beecher GR, Smith JC Jr. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem Suppl 1995;22:236-46.

26. Cheng CY, Chung WY, Szeto YT, Benzie IF. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial. Br J Nutr 2005;93:123-30.

27. Benzie IF, Chung WY, Wang J, et al. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr 2006;96:154-60.

28. Leung I, Tso M, Li W, Lam T. Absorption and tissue distribution of zeaxanthin and lutein in rhesus monkeys after taking Fructus lycii (Gou Qi Zi) extract. Invest Ophthalmol Vis Sci 2001;42:466-71.

29. Peng Y, Ma C, Li Y, et al. Quantification of zeaxanthin dipalmitate and total carotenoids in lycium fruits (Fructus Lycii). Plant Foods Hum Nutr 2005;60:161-4.

30. Zhou L, Leung I, Tso MO, Lam KW. The identification of dipalmityl zeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry. J Ocul Pharmacol Ther 1999;15:557-65.

31. Khachik F, Beecher GR, Smith JC Jr. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem Suppl 1995;22:236-46.

32. Cheng CY, Chung WY, Szeto YT, Benzie IF. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial. Br J Nutr 2005;93:123-30.

33. Benzie IF, Chung WY, Wang J, et al. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr 2006;96:154-60.

34. Leung I, Tso M, Li W, Lam T. Absorption and tissue distribution of zeaxanthin and lutein in rhesus monkeys after taking Fructus lycii (Gou Qi Zi) extract. Invest Ophthalmol Vis Sci 2001;42:466-71.

35. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.

36. Lycium. PDR [cited 2007 Aug 7]. Available from URL: www.pdrhealth.com/drug_info/nmdrugprofiles/herbaldrugs/101780.shtml.

37. Chinese Herbal Medicine Company. Chinese Traditional Formulation of Herbal Medicine. Shanghai: Scientific Publication, 1994:1598-608.

38. Cheng CY, Chung WY, Szeto YT, Benzie IF. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial. Br J Nutr 2005;93:123-30.

39. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium barbarum L.Ann Pharmacother 2001;35:1199-201.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.