Nutritional Supplement

Eleuthero

Parts Used & Where Grown

Eleuthero belongs to the Araliaceae family and is a distant relative of Asian ginseng (Panax ginseng). Also known commonly as touch-me-not and devil’s shrub, eleuthero has been most frequently nicknamed Siberian ginseng in this country. Eleuthero is native to the Taiga region of the Far East (southeastern part of Russia, northern China, Korea, and Japan). The root and the rhizomes (underground stem) are used medicinally.

How It Works

The constituents in eleuthero that have been most studied are the eleutherosides.1 Seven primary eleutherosides have been identified, with most of the research attention focusing on eleutherosides B and E.2 Eleuthero also contains complex polysaccharides (complex sugar molecules).3 These constituents may play a critical role in eleuthero’s ability to support immune function.

Eleuthero is an “adaptogen” (an agent that helps the body adapt to stress). It is thought to help support adrenal gland function when the body is challenged by stress.4

Eleuthero has been shown to enhance mental acuity and physical endurance without the letdown that comes with caffeinated products.2 Research has shown that eleuthero improves the use of oxygen by the exercising muscle.6 This means that a person is able to maintain aerobic exercise longer and recover from workouts more quickly. Preliminary research from Russia indicates it may be effective for this purpose.6 Other trials have been inconclusive8 or have shown no beneficial effect.9

Eleuthero may also support the body by helping the liver detoxify harmful toxins. It has shown a protective action in animal studies against chemicals such as ethanol, sodium barbital, tetanus toxoid, and chemotherapeutic agents.1 According to a test tube study eleuthero also helps protect the body during radiation exposure.11 Preliminary research in Russia has suggested that eleuthero may help alleviate side effects and help the bone marrow recover more quickly in people undergoing chemotherapy and radiation therapy for cancer.12

Eleuthero has been shown to be effective as a treatment for the common cold when combined with andrographis in a formula sometimes referred to as Kan Jang.13,14 Preliminary evidence also suggests that eleuthero may prove valuable in the long-term management of various diseases of the immune system, including HIV infection and chronic fatigue syndrome. Healthy people taking 2 teaspoons (10 ml) of tincture three times daily have been shown to have increased numbers of the immune cells (T4 lymphocytes) that have been found to decrease during HIV-infection and AIDS.15 Further human clinical trials are needed to confirm that eleuthero may be helpful for this disease.

References

1. Collisson RJ. Siberian ginseng (Eleutherococcus senticosus). Brit J Phytother 1991;2:61-71 [review].

2. Farnsworth NR, Kinghorn AD, Soejarto DD, Waller DP. Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen. In Economic and Medicinal Plant Research, vol 1, ed. Wagner H, Hikino HZ, Farnsworth NR. London: Academic Press, 1985, 155-215 [review].

3. Hikino H, Takahashi M, Otake K, konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F and G: glycans of Eleutherococcus senticosus roots. J Natural Prod 1986;49:293-7.

4. Wagner H, Nörr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1:63-76.

5. Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutherococcus senticosus extract on human working capacity. Planta Medica 1986;37:175-7.

6. Kelly GS. Sports nutrition: A review of selected nutritional supplements for endurance athletes. Alt Med Rev 1997;2:282-95 [review].

7. McNaughton L. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int Clin Nutr Rev 1989;9:32-5.

8. Ben-Hur E, Fulder S. Effect of P. ginseng saponins and Eleutherococcus S. on survival of cultured mammalian cells after ionizing radiation. Am J Chin Med 1981;9:48-56.

9. Kupin VI, Polevaia EB. Stimulation of the immunological reactivity of cancer patients by eleutherococcus extract. Vopr Onkol 1986;32:21-6 [in Russian].

10. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45.

11. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-98.

12. Bohn B, Nebe CT, Birr C. Flow cytometric studies with Eleutherococcus senticosus extract as an immunomodulating agent. Arzneim-Forsch Drug Res 1987;37:1193-6.

13. Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: Recent trends in the Soviet literature. J Ethnopharmacol 1982;6:339-53 [review].

14. Li XY. Immunomodulating Chinese herbal medicines. Mem Inst Oswaldo Cruz 1991;86 Suppl 2:159-64.

15. Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 2000;72:345-93.

16. Melchior J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Ness extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7:341-50.

17. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97.

18. Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized ginseng extract G 115 for potentiating vaccination against common cold and/or influenza syndrome. Drugs Exp Clin Res 1996;22:65-72.

19. Caceres DD, Hancke JL, Burgos RA, et al. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine 1999;6:217-23.

20. Hancke J, Burgos R, Caceres D, Wikman G. A double-blind study with a new monodrug Kan Jang: Decrease of symptoms and improvement in recovery from common colds. Phytother Res 1995;9:559-62.

21. Melchior J, Palm S, Wikman G. Controlled clinical study of standardized Andrographis paniculata extract in common cold-a pilot trial. Phytomedicine 1996;34:315-18.

22. Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman GA. Randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd. J Herb Pharmacother 2003;3:77-93.

23. Caceres DD, Hancke JL, Burgos RA, et al. Prevention of common colds with Andrographis paniculata dried extract: a pilot double blind trial. Phytomedicine 1997;4:101-104.

24. Spasov AA, Ostrovskij, OV, Chernikov MV, Wikman G. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 2004;18:47-53.

25. Melchior J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Ness extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7:341-50.

26. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97.

27. Cho YK, Kim Y, Choi M, et al. The effect of red ginseng and zidovudine on HIV patients. Int Conf AIDS 1994;10:215 [abstract no. PB0289].

28. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969;9:419-30 [review].

29. Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine 1999;6:287-300 [review].

30. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999;13:275-91 [review].

31. Wagner H, Nörr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1:63-76.

32. Deyama T, Nishibe S, Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 2001;22:1057-70 [review].

33. Farnsworth NR, Kinghorn AD, Soejarto D, Waller DP. Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen. Econ Med Plant Res 1985;1:156-215.

34. Cicero AFG, Derosa G, Brillante R, et al. Effects of Siberian ginseng (eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl2004;9:69-73.

35. Gaffney BT, Hugel HM, Rich PA. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci 2001;70:431-42.

36. Kelly GS. Sports nutrition: A review of selected nutritional supplements for endurance athletes. Alt Med Rev 1997;2:282-95 [review].

37. McNaughton L. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int Clin Nutr Rev 1989;9:32-5.

38. Dowling EA, Redondo DR, Branch JD, et al. Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. Med Sci Sports Exer 1996;28:482-9.

39. Eschbach LF, Webster MJ, Boyd JC, et al. The effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance. Int J Sport Nutr Exerc Metab 2000;10:444-51.

40. No authors listed. Monograph. <em>Eleutherococcus senticosus</em>. <em>Altern Med Rev</em> 2006;11:151-5.

41. Brown D. Licorice root - potential early intervention for chronic fatigue syndrome. Quart Rev Natural Med 1996;Summer:95-7.

42. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 69-77.

43. McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 45.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.