Nutritional Supplement

Bladderwrack

Parts Used & Where Grown

Bladderwrack is a type of brown algae (seaweed) that grows on the northern Atlantic and Pacific coasts of the United States and on the northern Atlantic coast and Baltic coast of Europe. The main stem of bladderwrack, known as the thallus, is used medicinally. The thallus has tough, air-filled pods or bladders to help the algae float—thus the name bladderwrack. Although bladderwrack is sometimes called kelp, that name is not specific to this species and should be avoided.

How It Works

There are three major active constituents in bladderwrack: iodine, alginic acid, and fucoidan.

The amount of iodine in bladderwrack is highly variable,1 probably as a result of different amounts of iodine in the water where it grows. A reasonable portion of bladderwrack may contain the U.S. adult recommended dietary allowance (RDA) of iodine (150 mcg). The RDA amount of iodine is believed to be necessary for maintenance of normal thyroid function in adults (infants and children need proportionally less). Thus, in people with insufficient iodine in their diet, bladderwrack may serve as a supplemental source of iodine. Either hypothyroidism or goiter due to insufficient intake of iodine may possibly improve with bladderwrack supplementation, though human studies have not confirmed this.

Alginic acid is a type of dietary fiber that can be used to help relieve constipation and diarrhea. However, human studies have not been done on how effective bladderwrack is for either of these conditions. An over-the-counter antacid, Gaviscon®, containing magnesium carbonate and sodium alginate (the sodium salt of alginic acid), has been shown to effectively relieve the symptoms of heartburn compared to other antacids in a double-blind study.2 However, bladderwrack has not been studied for use in people with heartburn. Bladderwrack might also help indigestion, though again clinical trials have not been conducted. Calcium alginate (the calcium salt of alginic acid) has shown promise as an agent to speed wound healing in animal studies3 but has not been demonstrated to be effective in humans.

Alginic acid has also been shown to inhibit HIV in the test tube.4 However, this effect has not been studied in humans. Alginic acid may help lower LDL (“bad”) cholesterol levels, according to animal studies.5 No human trials have studied this effect of bladderwrack. It is widely used in food and pharmaceuticals as a thickener and gelling agent.6

Fucoidan is another type of dietary fiber in bladderwrack that contains numerous sulfur groups. According to test tube and animal studies, this appears to give fucoidan several properties, such as lowering LDL cholesterol levels,5 lowering blood glucose levels,8 anti-inflammatory activity,9 possible anticoagulant effects,10 and antibacterial11 and anti-HIV activity.12 Though it has not been definitively proven, fucoidan is thought to prevent bacteria and viruses from binding to human cells, a necessary step in starting an infection, as opposed to killing the microbes directly.11,14 To date, no human clinical trials have been done with fucoidan or bladderwrack to support their use for any of these conditions.

References

1. Norman JA, Pickford CJ, Sanders TW, et al. Human intake of arsenic and iodine from seaweed based food supplements and health foods available in the UK. Food Addit Contam 1987;5:103-9.

2. Chevrel B. A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium-aluminum antacid gel. J Int Med Res 1980;8:300-3.

3. Barnett SA, Varley SJ. The effects of calcium alginate on wound healing. Ann R Coll Surgeons Engl 1987;69:153-5.

4. BĂ©ress A, Wassermann O, Bruhn T, et al. A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus. J Nat Prod 1993;56:478-88.

5. Vázquez-Freire MJ, Lamela M, Calleja JM. Hypolipidaemic activity of a polysaccharide extract from Fucus vesiculosus L. Phytother Res 1996;10:647-50.

6. Lahaye M, Kaeffer B. Seaweed dietary fibres: Structure, physico-chemical and biological properties relevant to intestinal physiology. Sci Aliments 1997;17:564-84 [review].

7. Vázquez-Freire MJ, Lamela M, Calleja JM. A preliminary study of hypoglycaemic activity of several polysaccharide extracts from brown algae: Fucus vesiculosus, Saccorhiza polyschides and Laminaria ochroleuca. Phytother Res 1996;10(suppl):S184-5.

8. Bartlett MR, Warren HS, Cowden WB, Parish DR. Effects of the anti-inflammatory compounds castanospermine, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates. Immunol Cell Biol 1994;72:367-74.

9. Church FC, Mead JB, Treanor RE, Whinna HC. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III and thrombin. J Biol Chem 1989;264:3618-23.

10. Criado MT, FerreirĂłs CM. Toxicity of an algal mucopolysaacharide for Escherichia coli and Neisseria meningitidis strains. Rev Esp Fisiol 1984;40:227-30.

11. Moen LK, Clark GF. A novel reverse transcriptase inhibitor from Fucus vesiculosus. Int Conf AIDS 1993;9(1):145, abstr. #PO-A03-0061.

12. Lederman S, Gulick R, Chess L. Dextran sulfate and heparin interact with CD4 molecules to inhibit the binding of coat protein (gp120) of HIV. J Immunol 1989;143:1149-54.

13. Golan R. Optimal Wellness. New York: Ballantine Books, 1995, 373-4.

14. Chevrel B. A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium-aluminum antacid gel. J Int Med Res 1980;8:300-3.

15. Blumenthal M, Busse WR, Goldberg A, et al, eds. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 167.

16. Kocharatana P, et al. Clinical trial of maeng-lak seeds used as a bulk laxative. Maharaj Nakornratchasima Hosp Med Bull 1985;9:120-36.

17. Muangman V, Siripraiwan S, Ratanaolarn K, et al. A clinical trial of Ocimum canum Sims seeds as a bulk laxative in elderly post-operative patients. Ramathibodi Med J 1985;8:154-8.

18. Eherer AH, Porter J, Fordtran JS. Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. Gastroenterol 1993;104:1007-12.

19. Barnett SA, Varley SJ. The effects of calcium alginate on wound healing. Ann R Coll Surgeons Engl 1987;69:153-5.

20. Barnett SA, Varley SJ. The effects of calcium alginate on wound healing. Ann R Coll Surgeons Engl 1987;69:153-5.

21. Norman JA, Pickford CJ, Sanders TW, et al. Human intake of arsenic and iodine from seaweed based food supplements and health foods available in the UK. Food Addit Contam 1987;5:103-9.

22. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996:124-6.

23. Mills SY. Out of the Earth: The Essential Book of Herbal Medicine. Middlesex, UK: Viking Arkana, 1991:514-6.

24. Björvell H, Rössner S. Long-term effects of commonly available weight reducing programmes in Sweden. Int J Obes 1986;11:67-71.

25. Mills SY. Out of the Earth: The Essential Book of Herbal Medicine. Middlesex, UK: Viking Arkana, 1991:514-6.

26. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998:315.

27. Harrell BL, Rudolph AH. Kelp diet: A cause of acneiform eruption. Arch Dermatol 1976;112:560 [letter].

28. Okamura K, Inoue K, Omae T. A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol 1978;88:703-12.

29. Kim JY, Kim KR. Dietary iodine intake and urinary iodine excretion in patients with thyroid diseases. Yonsei Med J. 2000;41:22-8.

30. Walkiw O, Douglas DE. Health food supplements prepared from kelp--a source of elevated urinary arsenic. Can Med Assoc J 1974;111:1301-2 [letter].

31. Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: A nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7 [letter].

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.