Health Condition

Menopause

  • Skin Moisturizers

    From the summer months when we are outdoors in wind and sun, to wintertime when indoor heating and frigid temperatures result in overly dry air, we’ve all experienced flaky skin and dry patches. Finding the right products to nourish dry skin is key to keeping your outermost layer happy and healthy. Keep the following points in mind as you consider skin moisturizers:

    • If you’ve never had severely dry skin in the past and develop it suddenly, talk to your doctor about this. Overly dry skin can signal other health issues such as hormone imbalances or an underactive thyroid gland, which require medical attention.
    • Many people confuse rosacea, a chronic condition involving facial skin inflammation, which can appear as redness, broken blood vessels, or acne-like skin eruptions, with true acne. Rosacea may look like acne that needs to be dried out with acne products, but a moisturizing rosacea-specialty product is a better option.
    •  If you’re pregnant, avoid moisturizing products that contain vitamin A–derived substances, such as retinol, retinal, or retinoids. These are not safe for use during pregnancy, and prescription vitamin A versions may even cause birth defects.
    • Facial Moisturizers

      What they are: Facial moisturizers are designed specifically for use on delicate facial skin. Some may be designed for specific areas of the face, such as around the eyes or mouth.

      Why to buy: Facial moisturizers are the right option to properly hydrate facial skin and keep it supple. Hand creams and other body moisturizing products tend to be too heavy; resist the temptation to use these instead of face-specific products.

      Things to consider: Pay attention to labels and use only as directed. For example, many products are not designed for use on eyelids or close to the eyes, and will sting if applied to these areas. Pick products to meet your needs. Facial moisturizers range from items to treat very dry faces to light moisturizers for acne-prone skin. Expensive may not be better. Ask your doctor or friends and family members for suggestions.

    • Body Moisturizers

      What they are: Body moisturizers come in lotions and thick creams and tend to be heavier than facial products and lighter than hand and foot moisturizers. They often contain humectants—substances to seal moisture into skin, and come with or without fragrance.

      Why to buy: Body moisturizers provide the right weight to keep you feeling soft and velvety all over. Many like to keep a good body moisturizer around so it’s always there to use when needed. Some people use them year round, while others only need them during specific dry seasons.

      Things to consider: Fragrances in lotions and creams are the most common culprit for allergic reactions. If you’ve had problems with moisturizers in the past, try a product formulated for sensitive skin or that is fragrance-free.

    • Moisturizers for Hands & Feet

      What they are: Moisturizers for hands and feet tend to be the heaviest, most moisturizing products available. Skin on hands and feet is thicker, tougher, and may be more exposed than other areas; these body parts may need a heartier product.

      Why to buy: These products are reasonably priced and can address serious dryness, such as cracked heels and chapped, irritated hands. They provide the deepest moisturizing for the areas that need it.

      Things to consider: These products are best for thicker, tougher skin, so avoid using on the face or other sensitive body areas where they may clog pores.

    • Specialty Moisturizers for Dry Patches

      What they are: Specialty moisturizers for dry patches are formulated to address a specific concern, such as dry elbows or knees. These products may contain substances that speed up cell turnover in the skin, so the outer layers of dead skin are shed more quickly. This allows the moisturizer to penetrate to where it is most needed.

      Why to buy: If you have a very dry body area, especially elbows, knees, heels, or hands, a specialty product can help get the problem under control.

      Things to consider: As with hand and feet moisturizers, these products are formulated for very tough, dry skin. They often do not work well on delicate facial skin.

  • Women's Vitamins

    Busy lives can make it challenging for many women to maintain a balanced diet—so look to various supplements to help support a healthy lifestyle. Did you know that heart disease is the number one killer of women? Many women’s supplements include folic acid and other important, heart-healthy nutrients. At different ages and life stages women have particular health and nutritional needs. To make sure you’re getting what you need, talk with your doctor.
    • Prenatal, Adult, & Senior Multivitamins

      What they are: Prenatal vitamins and multivitamins are specially formulated for women, packed with nutrients such as vitamin E, calcium, folic acid, and iron. Based on where you are in life, look for multivitamins with targeted nutrient combinations for teens, pregnant women, and seniors.

      Why to buy: A simple way to supplement your diet, women’s multivitamins contain a cross-section of the most important nutrients you need each day, generally in one or two easy-to-take doses. Most women’s formulas include calcium and vitamin D, both vital for bone health, as well as vitamin B6 and folic acid for heart health. During pregnancy and breast-feeding, many doctors recommend taking a prenatal vitamin with supportive nutrients for both mom and baby.

      Things to consider: Talk with your doctor before adding supplements to your self-care routine, especially if you are pregnant, nursing, or currently taking medications. Vitamins should be taken with food and water to avoid stomach upset and help your body best absorb the nutrients. Be sure to read product labels so you know exactly what you’re taking and how best to use it. Vegetarians should note that capsules are often made from animal gelatin, so look for vegetarian capsules or consider hard tablets as a better option.

    • Menopause Support

      What they are: Over-the-counter menopause formulas include various combinations of vitamins and herbs shown to be helpful for managing menopause symptoms. Tablets, capsules, and even chewable formulas are available.

      Why to buy: As women’s bodies change, their nutritional requirements do too. Explore phytoestrogens found in soy and flaxseed, soy and red clover isoflavones, evening primrose oil, black cohosh, and other nutrients shown to be helpful for reducing menopause symptoms like hot flashes and mood swings.

      Things to consider: If menopause symptoms are keeping you awake, look for nighttime formulas that include melatonin, valerian, and other naturally calming ingredients.

    • Creams & Lotions

      What they are: Creams and lotions offer women nourishing and moisturizing ingredients like Aloe vera and lanolin—often enhanced with nutrients like vitamins A, C, and E, lycopene, and green tea.

      Why to buy: Keep your skin hydrated and healthy with a variety of moisture-rich lotions and creams. Experts believe certain nutrients and antioxidants may help slow the effects of aging on your body. Most anti-aging products claim to support healthy tissue growth and help fight off free radicals.

      Things to consider: Keep in mind that vitamins are better absorbed through the digestive system rather than the skin and there is little evidence to support the benefits of directly applying vitamins to the skin. Most anti-aging claims are not backed by much science. If you have sensitive skin, try hypo-allergenic and unscented creams and lotions.

  • Sleep Aids

    Characterized by difficulty falling asleep, waking up often, and poor-quality sleep, insomnia can take a toll on health and leave a person exhausted and cranky. If you have trouble sleeping, an occasional over-the-counter sleep aid may help you get the sleep you need. This buying guide will help you find a sleep aid to fit your health goals, lifestyle, and budget. Keep the following additional points in mind as you choose a product:

    • Everyone has a sleepless night here or there, but if persistent insomnia is new for you, talk to your doctor. It may signal a more serious health problem.
    • When selecting a product, consider medications you use and health conditions you have. Consult your doctor or pharmacist if unsure about whether any particular sleep aid is safe for you.
    • If you have a history of mental health conditions, such as anxiety or depression, do not use sleep aids without first discussing it with your doctor. Some of these products may intensify mental health issues and many can interfere with medications used to manage mental health issues.
    • Use sleep aids carefully, follow all package directions, and always compare ingredients to avoid accidentally taking two medications together that contain the same active ingredients.
    • Do not use sleep aids and alcohol together. Alcohol increases the sedative effects of over-the-counter sleep medications; combining the two can lead to dizziness or fainting.
    • Over-the-counter medications work best when taken occasionally. When taken long-term, these medications can lose their effectiveness and also cause some dependency.
    • Over-the-Counter Medications

      What they are: There are two over-the-counter medications approved for use as sleep aids to manage occasional insomnia:

      • Diphenhydramine. The active ingredient in the antihistamine Benadryl, this medication also is found in brand name sleep aids such as Tylenol PM and Sominex, as well as numerous generic sleep aids.
      • Doxylamine. The active ingredient in Unisom, doxylamine also is found in generic sleep aids.

      Why to buy: Diphenhydramine and doxylamine effectively induce drowsiness and lead to uninterrupted sleep for many people. These products come in many forms, including soft gels, tablets, caplets, and chewables. Soft gels and chewables are faster acting than tablets.

      Things to consider: You should not take diphenhydramine or doxylamine if you are pregnant or breast-feeding, or if you have glaucoma, heart problems, enlarged prostate, or ulcers. Additionally, do not take doxylamine if you have or have had asthma or bronchitis. Some people feel groggy the next day after taking these medications. For very few people, especially children, diphenhydramine and doxylamine may cause agitation and alertness, which will not help insomnia!

    • Herbs, Dietary Supplements, & Other Natural Sleep Aids

      What they are: Natural sleep aids include dietary supplements, herbs, and other non-medication substances. Common natural sleep aids include:

      • Melatonin. A hormone naturally produced by the body to induce sleep, which can be taken as a dietary supplement as well
      • Valerian, chamomile, lemon balm, and passionflower. Herbs believed to have sleep-inducing and relaxation properties
      • Kava kava. An herb with relaxation properties, which is no longer recommended by many health care providers due to potential problems with liver toxicity
      • Theanine. A substance found in green tea that can promote relaxation and sleep.
      • Magnesium. A mineral that the body uses to relax muscles
      • Lavender. An aromatherapy herb (smelled, not taken orally) that may promote relaxation and restfulness
      • Hops. A plant best known as a flavoring component for beer, which can be used as a dietary supplement to manage insomnia
      • L-tryptophan. An amino acid (a building block for protein) that may improve sleep for some people

      Why to buy: Some of these herbs and dietary supplements have research to support that they may be helpful for managing insomnia, including melatonin, valerian, chamomile, passionflower, theanine, magnesium, hops, and L-tryptophan. They may be less likely to cause next-day grogginess than over-the-counter sleep medications.

      Things to consider: Natural does not always mean safe. All dietary supplements and herbs should be carefully reviewed with your healthcare provider or pharmacist. If you are managing a health condition, this will help to ensure a supplement is safe to combine with medications you are using. Use plant- and herb-based natural sleep aids with caution if you have hay fever or seasonal allergies; some of these products may cause allergic reactions in susceptible individuals. Natural sleep aids may not be safe for people with a history of mental health conditions, such as anxiety or depression. If in doubt, talk to your doctor first. Magnesium can have laxative effects, so start with a low dose to assess your tolerance to this mineral.

    • Stop-Snoring Products

      What they are: Stop-snoring products are designed to decrease bothersome snoring, either through physically opening breathing passageways, or by changing how the muscles in the mouth and throat are contracting or relaxing. Mouthpieces and nasal clips and strips are used to open breathing passages. Homeopathic, herbal, and other natural substances are taken orally or sprayed into the throat to ease snoring.

      Why to buy: Some people find stop-snoring products to be helpful. They are relatively inexpensive and the products designed to physically open breathing passages are safe for nearly everyone.

      Things to consider: Snoring can signal a serious health condition, such as sleep apnea. If you’ve developed snoring recently, if your snoring is severe, or if you are groggy most of the time during the day, talk to your doctor before you try to self-treat snoring.

References

1. Wiklund IK, Mattson LA, Lindgren R, et al. Effects of a standardized ginseng extract on quality of life and psychological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharm Res 1999;19:89-99.

2. Kim SY, Seo SK, Choi YM, et al. Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial. Menopause 2012;19:461-6.

3. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecological disorders. Advances Therapy 1998;15:45-53.

4. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005;20:30-5.

5. Lieberman S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. J Womens Health 1998;7:525-9.

6. Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006;145:869-79.

7. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

8. Lee MS, Shin BC, Yang EJ, et al. Maca (Lepidium meyenii) for treatment of menopausal symptoms: A systematic review. Maturitas 2011;70:227-33.

9. Yang HM, Liao MF, Zhu SY, et al. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand 2007;86:978-85.

10. Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med 2013;58:39-46.

11. Lee JR. Natural Progesterone. The multiple roles of a remarkable hormone. Sebastipol, CA: BLL Publishing, 1993, 31-7.

12. Gaby AR. Commentary. Nutr Healing 1996;June:1,10-1.

13. Wright JV. Hormones for menopause. Nutr Healing 1996;June:1-2,9.

14. Greendale GA, Reboussin BA, Hogan P, et al. Symptom relief and side effects of postmenopausal hormones: results from the Postmenopausal Estrogen/Progestin Interventions Trial. Obstet Gynecol 1998;92:982-8.

15. Leonetti HB, Long S, Anasti JM. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 1999;94:225-8.

16. Fitzpatrick LA, Pace C, Wiita B. Comparison of regimens containing oral micronized progesterone or medroxyprogesterone acetate on quality of life in postmenopausal women: a cross-sectional survey. J Women's Health Gender-Based Med 2000;9:381-7.

17. Bullock JL, Massey FM, Gambrell RD Jr. Use of medroxyprogesterone acetate to prevent menopausal symptoms. Obstet Gynecol 1975;46:165-8.

18. Morrison JC, Martin DC, Blair RA, et al. The use of medroxyprogesterone acetate for relief of climateric symptoms. Am J Obstet Gynecol 1980 138:99-104.

19. Schiff I, Tulchinsky D, Cramer D, Ryan KJ. Oral medroxyprogesterone in the treatment of postmenopausal symptoms. JAMA 1980;244:1443-5.

20. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

21. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

22. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

23. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

24. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

25. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

26. Lipovac M, Chedraui P, Gruenhut C, et al. Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts. Maturitas 2010;65:258-261.

27. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 420-1 [review].

28. De Leo V, Lanzetta D, Cazzavacca R, Morgante G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent] [Article in Italian] Minerva Ginecol 1998;50:207-11.

29. Park JY, Kim KH. A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms. Climacteric 2016;19:574–80.

30. Perloff WH. Treatment of the menopause. Am J Obstet Gynecol 1949;58:684-94.

31. Gozan HA. The use of vitamin E in treatment of the menopause. NY State J Med 1952;52:1289.

32. Christy CJ. Vitamin E in menopause: Preliminary report of experimental and clinical study. Am J Obstet Gynecol 1945:50:84.

33. Finkler RS. The effect of vitamin E in the menopause. J Clin Endocrinol Metab 1949;9:89-94.

34. Rubenstein BB. Vitamin E diminishes the vasomotor symptoms of menopause. Fed Proc 1948;7:106 [abstract].

35. Blatt MHG, Weisbader H, Kupperman HS. Vitamin E and climacteric syndrome: failure of effective control as measured by menopausal index. Arch Intern Med 1953;91:792-9.

36. Ziaei S, Kazemnejad A, Zareai M. The effect of vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest 2007;64:204-7.

37. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

38. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

39. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

40. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

41. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

42. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

43. Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999;16:177-86.

44. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

45. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

46. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

47. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

48. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

49. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

50. Stomati M, Rubino S, Spinetti A, et al. Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women. Gynecol Endocrinol 1999;13:15-25.

51. Barnhart KT, Freeman E, Grisso JA, et al. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab 1999;84:3896-902.

52. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

53. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

54. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

55. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

56. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

57. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

58. CJ Smith. Non-hormonal control of vaso-motor flushing in menopausal patients. Chicago Med 1964;67:193-5.

59. Pruthi S, Thompson SL, Novotny PJ, et al. Pilot evaluation of flaxseed for the management of hot flashes. J Soc Integr Oncol 2007;5:106-12.

60. Simbalista RL, Sauerbronn AV, Aldrighi JM, Areas JAG. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. J Nutr 2010;140:293-7.

61. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

62. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

63. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

64. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

65. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

66. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

67. REF:Park H, Parker GL, Boardman CH, et al. A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients. Support Care Cancer 2011;19:859-63.

68. Park H, Qin R, Smith TJ, Atherton PJ, et al. North Central Cancer Treatment Group N10C2 (Alliance): a double-blind placebo-controlled study of magnesium supplements to reduce menopausal hot flashes. Menopause 2014;Nov 24:[Epub ahead of print].

69. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

70. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

71. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

72. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

73. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

74. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

75. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 420-1 [review].

76. De Leo V, Lanzetta D, Cazzavacca R, Morgante G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent] [Article in Italian] Minerva Ginecol 1998;50:207-11.

77. Casini ML, Marelli G, Papaleo E, Ferrari A, D'Ambrosio F, Unfer V. Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study. Fertil Steril 2006;85:972-8.

78. Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL, Lamia CA. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000;7:236-42.

79. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.

80. Uebelhack R, Blohmer JU, Graubaum HJ, et al. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006;107:247-55.

81. Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999;16:177-86.

82. Al-Akoum M, Maunsell E, Verreault R, et al. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009;16:307-14.

83. CJ Smith. Non-hormonal control of vaso-motor flushing in menopausal patients. Chicago Med 1964;67:193-5.

84. Crawford AM. The Herbal Menopause Book. Freedom, CA: Crossing Press, 1996.

85. Hudson TS, Standish L, Breed C, et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1997;7(1):73-7.

86. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6.

87. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 1999;84:895-8.

88. Tice JA, Ettinger B, Ensrud K, et al. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003;290:207-14.

89. van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

90. Toriizuka K, Okumura M, Iijima K, et al. Acupuncture inhibits the decrease in brain catecholamine contents and the impairment of passive avoidance task in ovariectomized mice. Acupunct Electrother Res 1999;24:45-57.

91. Wyon Y, Lindgren R, Hammar M, Lundeberg T. Acupuncture against climacteric disorders? Lower number of symptoms after menopause. Lakartidningen 1994;91:2318-22 [in Swedish].

92. Popivanov P. Menopausal indices as criteria for the effectiveness of acupuncture treatment of the climacteric syndrome. Vutr Boles 1983;22:110-3 [in Bulgarian].

93. Kraft K, Coulon S. Effect of a standardized acupuncture treatment on complains, blood pressure and serum lipids of hypertensive, postmenopausal women. A randomized, controlled clinical study. Forsch Komplementarmed 1999;6:74-9 [in German].

94. Lianzhong W, Xin Z. 300 cases of menopausal syndrome treated by acupuncture. J Trad Chin Med 1998;18:259-62.

95. Baird DD, Umbach DM, Landsedell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995;80:1685-90.

96. Cassidy A, Bingham S, Setchell KD. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 1994;60:333-40.

97. Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol 1996;87:897-904 [review].

98. Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998;91:6-11.

99. Albertazzi P, Pansini F, Bottazzi M, et al. Dietary soy supplementation and phytoestrogen levels. Obstet Gynecol 1999;94:229-31.

100. Brezinski A, Adlercreutz H, Shaoul R, et al. Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997;4:89-94.

101. Han KK, Soares JM Jr, Haidar MA, et al. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002;99:389-94.

102. Kaari C, Haidar MA, Junior JMS, et al. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas2006;53:49-58.

103. Welty FK, Lee KS, Lew NS, et al. The association between soy nut consumption and decreased menopausal symptoms. J Womens Health 2007;16:361-9.

104. Casini ML, Marelli G, Papaleo E, Ferrari A, D'Ambrosio F, Unfer V. Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study. Fertil Steril 2006;85:972-8.

105. Ivarsson T, Spetz AC, Hammar M. Physical exercise and vasomotor symptoms in postmenopausal women. Mauritas 1998;29:139-46.

106. Hammar M, Berg G, Lindgren R. Does physical exercise influence the frequency of postmenopausal hot flushes? Acta Obstet Gynecol Scand 1990;69:409-12.

107. Slaven L, Lee C. Mood and symptom reporting among middle-aged women: the relationship between menopausal status, hormone replacement therapy, and exercise participation. Health Psychol 1997;16:203-8.

108. Staropoli CA, Flaws JA, Bush TL, Moulton AW. Predictors of menopausal hot flashes. J Womens Health 1998;7:1149-55.

109. Greenberg G, Thompson SG, Meade TW. Relation between cigarette smoking and use of hormonal replacement therapy for menopausal symptoms. J Epidemiol Community Health 1987;41:26-9.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.