Triazolam
Common brand names:
HalcionTriazolam is used for the short-term treatment of insomnia, and is in a family of drugs known as benzodiazepines.
Summary of Interactions with Vitamins, Herbs, & Foods
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Negative Interactions
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Potential Negative Interaction
Triazolam
Grapefruit
Drinking grapefruit juice with triazolam dramatically increases the amount of drug absorbed and the amount of time it stays in the body. Though the clinical significance of this interaction is unknown, some people may experience increased side effects, such as morning grogginess, dizziness, and poor coordination. Therefore, people taking triazolam should probably avoid drinking grapefruit juice or eating grapefruit for the duration of therapy.
GrapefruitTriazolam- Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461-3.
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Potential Negative Interaction
Triazolam
Pomegranate
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with triazolam in the same way that grapefruit juice does.
PomegranateTriazolam- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
- Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
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Supportive Interactions
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Support Medicine
Triazolam
Melatonin
A preliminary study showed that taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone. The results also indicated that less triazolam is needed when melatonin and triazolam are taken together, which might reduce side effects such as morning grogginess. Additional research is needed to determine whether individuals taking triazolam should also take melatonin.
MelatoninTriazolam- Ferini-Strambi L, Zucconi M, Biella G, et al. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16:744-7..
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Support Medicine
Triazolam
Vinpocetine
In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine. Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or triazolam specifically.
VinpocetineTriazolam- Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325-31.
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