Drug

Sennosides-Docusate Sodium

Summary of Interactions with Vitamins, Herbs, & Foods

  • Supportive Interactions

    2
    • Docusate

      Magnesium

      Replenish Depleted Nutrients

      A woman and her newborn infant experienced low blood levels of magnesium, which was possibly due to chronic use of docusate throughout and after pregnancy. Controlled research is necessary to determine whether people taking docusate for long periods of time need to supplement magnesium.

      Magnesium
      Docusate
      ×
      1. Schindler AM. Isolated neonatal hypomagnesaemia associated with maternal overuse of stool softener. Lancet 1984;2:822 [letter].
    • Docusate

      Potassium

      Replenish Depleted Nutrients

      Taking docusate increases the amount of potassium excreted from the body in the stool. Whether people taking docusate for long periods of time need to increase their intake of potassium is unknown.

      Potassium
      Docusate
      ×
      1. Moriarty KJ, Kelly MJ, Beetham R, Clark ML. Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum. Gut 1985;26:1008-13.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

Copyright © 2025 TraceGains, Inc. All rights reserved.

RxAnswers™ is a copyrighted product from TraceGains.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

There are some limitations on the information provided in “Nutrient Interactions.” Do NOT rely solely on the information in this article. Please read the disclaimer.

Learn more about TraceGains, the company.

Learn more about the authors of RxAnswers.

TraceGains and/or its suppliers make no warranties or representations as to the accuracy or completeness of this content herein or that of any organization referred or linked to within this content and will not be liable for any damages arising out of your access to or use of any information found herein or that of any organization referred to within this content.

Information expires December 2025.