Drug

Risperidone Microspheres

Summary of Interactions with Vitamins, Herbs, & Foods

  • Supportive Interactions

    6
    • Risperidone

      Glycine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Glycine
      Risperidone
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Risperidone Microspheres

      Glycine

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a small double-blind study, people with schizophrenia being treated with risperidone experienced an improvement in their symptoms when glycine was added to their treatment regimen. The initial amount of glycine used was 4 grams per day; this was increased gradually over a period of 10 to 17 days to a maximum of 0.8 grams per 2.2 pounds of body weight per day.

      Glycine
      Risperidone Microspheres
      ×
      1. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71.
    • Risperidone

      Licorice

      Reduce Side Effects

      An Oriental herb formula containing Glycyrrhiza radix (licorice root) and Paeoniae radix (white peony root) successfully restored menses in a 28-year-old woman who had developed amenorrhea (lack of menstruation) while taking risperidone. Discontinuation of these herbs while the woman continued taking risperidone again led to disruption of her menses. In another study, treatment with this same formula restored menses in 6 of 18 women who had developed amenorrhea or oligomenorrhea (infrequent menstruation) from taking risperidone. Controlled research is needed to determine whether supplementation with licorice and peony might help prevent amenorrhea in women taking risperidone.

      Licorice
      Risperidone
      ×
      1. Yamada K, Kanba S, Yagi G, Asai M. Herbal medicine (shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. J Clin Psychopharmacol 1999;19:380-1.
      2. Yuan HN, Wang CY, Sze CW, et al. A randomized, crossover comparison of herbal medicine and bromocriptine against resperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol 2008; 28:264-70.
    • Risperidone

      Peony

      Reduce Side Effects

      An Oriental herb formula containing Glycyrrhiza radix (licorice root) and Paeoniae radix (white peony root) successfully restored menses in a 28-year-old woman who had developed amenorrhea (lack of menstruation) while taking risperidone. Discontinuation of these herbs while the woman continued taking risperidone again led to disruption of her menses. In another study, treatment with this same formula restored menses in 6 of 18 women who had developed amenorrhea or oligomenorrhea (infrequent menstruation) from taking risperidone. Controlled research is needed to determine whether supplementation with licorice and peony might help prevent amenorrhea in women taking risperidone.

      Peony
      Risperidone
      ×
      1. Yamada K, Kanba S, Yagi G, Asai M. Herbal medicine (shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. J Clin Psychopharmacol 1999;19:380-1.
      2. Yuan HN, Wang CY, Sze CW, et al. A randomized, crossover comparison of herbal medicine and bromocriptine against resperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol 2008; 28:264-70.
    • Risperidone

      Vitamin B6

      Reduce Side Effects

      Vitamin E along with vitamin B6 was used to treat a side effect of risperidone called neuroleptic malignant syndrome in a 74-year-old woman, and results were encouraging. However, whether vitamin E and vitamin B6 supplementation might help prevent this condition in people taking risperidone is unknown.

      Vitamin B6
      Risperidone
      ×
      1. Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus vitamin B6 treatment of risperidone-related neuroleptic malignant syndrome. J Psychopharmacol 1998;12:220-1.
    • Risperidone

      Vitamin E

      Reduce Side Effects

      Vitamin E along with vitamin B6 was used to treat a side effect of risperidone called neuroleptic malignant syndrome in a 74-year-old woman, and results were encouraging. However, whether vitamin E and vitamin B6 supplementation might help prevent this condition in people taking risperidone is unknown.

      Vitamin E
      Risperidone
      ×
      1. Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus vitamin B6 treatment of risperidone-related neuroleptic malignant syndrome. J Psychopharmacol 1998;12:220-1.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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