Drug

Heparin (Porcine) in NS

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    9
    • Heparin

      Dong Quai

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Dong Quai
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
    • Heparin

      Fenugreek

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Fenugreek
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
    • Heparin

      Ginger

      Potential Negative Interaction

      Ginger has been shown to reduce platelet stickiness in test tubes. Although there are no reports of interactions with anticoagulant drugs, people should consult a healthcare professional if they are taking an anticoagulant and wish to use ginger.

      Ginger
      Heparin
      ×
      1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 135-7.
    • Heparin

      Ginkgo

      Potential Negative Interaction

      Ginkgo extracts may reduce the ability of platelets to stick together, possibly increasing the tendency toward bleeding. Standardized extracts of ginkgo have been associated with two cases of spontaneous bleeding, although the ginkgo extracts were not definitively shown to be the cause of the problem. People taking heparin should consult with a physician knowledgeable about botanical medicines if they are considering taking ginkgo.

      Ginkgo
      Heparin
      ×
      1. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992;340:1136-9 [review].
      2. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 1997;336:1108 [letter].
      3. Matthews MK Jr. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998;50:1933-4 [letter].
    • Heparin

      Horse Chestnut

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Horse Chestnut
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
    • Heparin

      Red Clover

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Red Clover
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
    • Heparin

      Reishi

      Potential Negative Interaction

      As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

      Reishi
      Heparin
      ×
      1. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publications, 1998,166-9.
    • Heparin

      Sweet Clover

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Sweet Clover
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
    • Heparin

      Sweet Woodruff

      Potential Negative Interaction

      Although there are no specific studies demonstrating interactions with anticoagulants, the following herbs contain coumarin-like substances that may interact with heparin and could conceivably cause bleeding. These herbs include dong quai, fenugreek, horse chestnut, red clover, sweet clover, and sweet woodruff. People should consult a healthcare professional if they’re taking an anticoagulant and wish to use one of these herbs.

      Sweet Woodruff
      Heparin
      ×
      1. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician's Guide. New York: Pharmaceutical Products Press, 1999, 313-5.
  • Supportive Interactions

    1
    • Heparin

      Vitamin D

      Replenish Depleted Nutrients

      Heparin may interfere with activation of vitamin D in the body.Osteoporosis (thinning of the bone) has been reported in patients who received high amounts of heparin for several months. Osteopenia (decreased bone density) has been reported in women who received heparin therapy during pregnancy.

      Vitamin D
      Heparin
      ×
      1. Aarskog D, Aksens L, Markestad TK, et al. Heparin induced inhibition of 1,25-dihydroxyvitamin D formation. Am J Obstet Gynecol 1984;148:1141-2.
      2. Majerus PW, Broze GJ Jr, Miletich JP, Tollefsen DM. Anticoagulant, thrombolytic, and antiplatelet drugs. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. New York: McGraw-Hill 1996, 1346.
      3. Wise PH, Hall AS. Heparin induced osteopenia in pregnancy. BMJ 1980;281:110-1.
      4. Haram K, Hervig T, Thordarson H, Aksnes L. Osteopenia caused by heparin treatment in pregnancy. Acta Obstet Gynecol Scand 1993;72:674-5.
  • Explanation Required

    2
    • Heparin

      Digitalis

      Needs Explanation

      Digitalis (Digitalis purpurea) refers to a group of plants commonly called foxglove, which contains chemicals related to the drug digoxin. Digitalis may interfere with the anticoagulant action of heparin, reducing its action. Digitalis should only be used under the direct supervision of a doctor trained in its use.

      Digitalis
      Heparin
      ×
      1. Threlkeld DS, ed. Blood Modifiers, Anticoagulants, Heparin. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1997, 87a-7f.
    • Heparin

      Potassium

      Needs Explanation

      Heparin therapy may cause hyperkalemia (abnormally high potassium levels). Potassium supplements, potassium-containing salt substitutes (No Salt®, Morton Salt Substitute®, and others), and even high-potassium foods (primarily fruit) should be avoided by persons on heparin therapy, unless directed otherwise by their doctor.

      Potassium
      Heparin
      ×
      1. Threlkeld DS, ed. Blood Modifiers, Anticoagulants, Heparin. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1997, 87a-7f.
      2. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307-14 [review].
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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