Drug

Estropipate

Common brand names:

Ogen

Estropipate is used both to treat moderate to severe symptoms associated with menopause, including hot flashes and vaginal dryness, and to prevent osteoporosis. It is in a class of drugs known as estrogens.

There are currently no reported nutrient or herb interactions specifically involving estropipate; however, since it is an estrogen, estropipate might interact with similar compounds. For more information, refer to the estrogen section.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Negative Interactions

    1

    • Estropipate

      Zinc

      Potential Negative Interaction

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion. The clinical significance of this interaction remains unclear.

      Zinc
      Estropipate
      ×
      1. Herzberg M, Lusky A, Blonder J, Frenkel. The effect of estrogen replacement therapy on zinc in serum and urine. Obstet Gynecol 1996;87:1035-40.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

Copyright © 2025 TraceGains, Inc. All rights reserved.

RxAnswers™ is a copyrighted product from TraceGains.

This information is intended only for residents of the United States. Products sold under the same brand names in other countries may contain different ingredients.

There are some limitations on the information provided in “Nutrient Interactions.” Do NOT rely solely on the information in this article. Please read the disclaimer.

Learn more about TraceGains, the company.

Learn more about the authors of RxAnswers.

TraceGains and/or its suppliers make no warranties or representations as to the accuracy or completeness of this content herein or that of any organization referred or linked to within this content and will not be liable for any damages arising out of your access to or use of any information found herein or that of any organization referred to within this content.

Information expires December 2025.