Drug

Clorazepate

Common brand names:

Tranxene T-Tab, Tranxene-SD

Clorazepate is used to treat the symptoms of anxiety, including restlessness, insomnia, and worry; it is also used for convulsions and symptoms associated with acute alcohol withdrawal. It is in a class of drugs known as benzodiazepines.

Summary of Interactions with Vitamins, Herbs, & Foods

  • Supportive Interactions

    1

    • Clorazepate

      Vinpocetine

      Support Medicine

      In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine. Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or clorazepate specifically.

      Vinpocetine
      Clorazepate
      ×
      1. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325-31.

  • Explanation Required

    1

    • Clorazepate

      L-Tryptophan

      Needs Explanation

      Test tube studies show that L-tryptophan and clorazepate dipotassium interact in the blood in such a way that the actions of the drug may be enhanced when high amounts of L-tryptophan are ingested. Controlled research is needed to determine the significance of this interaction and to investigate possible interactions between clorazepate and 5-hydroxytryptophan, a supplement related to L-tryptophan.

      L-Tryptophan
      Clorazepate
      ×
      1. Coassolo P, Briand C, Bourdeaux M, Sari JC. Microcalorimetric method to determine competitive binding. Action of a psychotropic drug (dipotassium clorazepate) on L-tryptophan human serum albumin complex. Biochem Biophys Acta 1978;538:512-20.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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